Genetic variation in the promoter region of the basic
Fibroblast Growth Factor gene (bFGF)

J 2002

Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF)

BERÁNEK, Michal; Svatava TSCHÖPLOVÁ; Kateřina KAŇKOVÁ; Viera KUHROVÁ; Jiří VÁCHA et al.

Základní údaje

Originální název

Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF)

Autoři

BERÁNEK, Michal; Svatava TSCHÖPLOVÁ; Kateřina KAŇKOVÁ; Viera KUHROVÁ a Jiří VÁCHA

Vydání

Human Immunology, USA, ELSEVIER SCIENCE INC, 2002, 0198-8859

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.573

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/02:00006679

Organizační jednotka

Lékařská fakulta

UT WoS

000181137600008

Klíčová slova anglicky

bFGF; genetic polymorphism; linkage disequilibrium

Štítky

bFGF, genetic polymorphism, linkage disequilibrium

Změněno: 24. 6. 2009 15:25, prof. MUDr. Kateřina Kaňková, Ph.D.

Anotace

V originále

Basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family that possess broad mitogenic and cell survival activities and is involved in a variety of biological processes. We investigated possible genetic polymorphism in the promoter and 5 flanking region of the bFGF gene. Polymorphism was analysed by means of heteroduplex analysis, fragments with altered mobility were sequenced. Three novel substitutions (-553T/A, -834T/A and -921C/G) were identified in the promoter region. Allele frequencies in a sample of healthy Caucasian subjects (n=126) were determined by polymerase chain reactions followed by restriction analyses with specific endonucleases. The frequencies of the mutated alleles (-553A, -834A and 921G) were 0.04, 0.05 and 0.14, respectively. Newly identified variants in the bFGF gene promoter appear to be common polymorphisms in the Czech population.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

BERÁNEK, Michal; Svatava TSCHÖPLOVÁ; Kateřina KAŇKOVÁ; Viera KUHROVÁ a Jiří VÁCHA. Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF). Human Immunology. USA: ELSEVIER SCIENCE INC, 2002, roč. 64, č. 3, s. 374-377. ISSN 0198-8859.

@article{406505,
   author = {Beránek, Michal and Tschöplová, Svatava and Kaňková, Kateřina and Kuhrová, Viera and Vácha, Jiří},
   article_location = {USA},
   article_number = {3},
   keywords = {bFGF; genetic polymorphism; linkage disequilibrium},
   language = {eng},
   issn = {0198-8859},
   journal = {Human Immunology},
   title = {Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF)},
   volume = {64},
   year = {2002}
}

TY  - JOUR
ID  - 406505
AU  - Beránek, Michal - Tschöplová, Svatava - Kaňková, Kateřina - Kuhrová, Viera - Vácha, Jiří
PY  - 2002
TI  - Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF)
JF  - Human Immunology
VL  - 64
IS  - 3
SP  - 374-377
EP  - 374-377
PB  - ELSEVIER SCIENCE INC
SN  - 01988859
KW  - bFGF
KW  - genetic polymorphism
KW  - linkage disequilibrium
N2  - Basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family that possess broad mitogenic and cell survival activities and is involved in a variety of biological processes. We investigated possible genetic polymorphism in the promoter and 5 flanking region of the bFGF gene. Polymorphism was analysed by means of heteroduplex analysis, fragments with altered mobility were sequenced. Three novel substitutions (-553T/A, -834T/A and -921C/G) were identified in the promoter region. Allele frequencies in a sample of healthy Caucasian subjects (n=126) were determined by polymerase chain reactions followed by restriction analyses with specific endonucleases. The frequencies of the mutated alleles (-553A, -834A and 921G) were 0.04, 0.05 and 0.14, respectively. Newly identified variants in the bFGF gene promoter appear to be common polymorphisms in the Czech population.
ER  -

BERÁNEK, Michal; Svatava TSCHÖPLOVÁ; Kateřina KAŇKOVÁ; Viera KUHROVÁ a Jiří VÁCHA. Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF). \textit{Human Immunology}. USA: ELSEVIER SCIENCE INC, 2002, roč.~64, č.~3, s.~374-377. ISSN~0198-8859.

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