| BERÁNEK, Michal, Svatava TSCHÖPLOVÁ, Kateřina KAŇKOVÁ, Viera KUHROVÁ a Jiří VÁCHA. Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF). Human Immunology. USA: ELSEVIER SCIENCE INC, 2002, roč. 64, č. 3, s. 374-377. ISSN 0198-8859. |
Další formáty:
BibTeX
LaTeX
RIS
@article{406505,
author = {Beránek, Michal and Tschöplová, Svatava and Kaňková, Kateřina and Kuhrová, Viera and Vácha, Jiří},
article_location = {USA},
article_number = {3},
keywords = {bFGF; genetic polymorphism; linkage disequilibrium},
language = {eng},
issn = {0198-8859},
journal = {Human Immunology},
title = {Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF)},
volume = {64},
year = {2002}
}
TY - JOUR
ID - 406505
AU - Beránek, Michal - Tschöplová, Svatava - Kaňková, Kateřina - Kuhrová, Viera - Vácha, Jiří
PY - 2002
TI - Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF)
JF - Human Immunology
VL - 64
IS - 3
SP - 374-377
EP - 374-377
PB - ELSEVIER SCIENCE INC
SN - 01988859
KW - bFGF
KW - genetic polymorphism
KW - linkage disequilibrium
N2 - Basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family that possess broad mitogenic and cell survival activities and is involved in a variety of biological processes. We investigated possible genetic polymorphism in the promoter and 5 flanking region of the bFGF gene. Polymorphism was analysed by means of heteroduplex analysis, fragments with altered mobility were sequenced. Three novel substitutions (-553T/A, -834T/A and -921C/G) were identified in the promoter region. Allele frequencies in a sample of healthy Caucasian subjects (n=126) were determined by polymerase chain reactions followed by restriction analyses with specific endonucleases. The frequencies of the mutated alleles (-553A, -834A and 921G) were 0.04, 0.05 and 0.14, respectively. Newly identified variants in the bFGF gene promoter appear to be common polymorphisms in the Czech population.
ER -
BERÁNEK, Michal, Svatava TSCHÖPLOVÁ, Kateřina KAŇKOVÁ, Viera KUHROVÁ a Jiří VÁCHA. Genetic variation in the promoter region of the basic Fibroblast Growth Factor gene (bFGF). \textit{Human Immunology}. USA: ELSEVIER SCIENCE INC, 2002, roč.~64, č.~3, s.~374-377. ISSN~0198-8859.
|
