| BRABEC, Viktor, Kamila NEPLECHOVÁ, Jana KAŠPÁRKOVÁ and Nicholas FARRELL. Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups. Journal of Biological Inorganic Chemistry. Heidelberg: Springer Verlag, 2000, vol. 2000, 5/3, p. 364-368. ISSN 0949-8257. |
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@article{485464,
author = {Brabec, Viktor and Neplechová, Kamila and Kašpárková, Jana and Farrell, Nicholas},
article_location = {Heidelberg},
article_number = {5/3},
keywords = {DNA;cisplatin; transplatin; cross-link; dimethyl sulfate},
language = {eng},
issn = {0949-8257},
journal = {Journal of Biological Inorganic Chemistry},
title = {Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups},
url = {http://link.springer.de/link/service/journals/00775/tocs/t0005003.htm},
volume = {2000},
year = {2000}
}
TY - JOUR
ID - 485464
AU - Brabec, Viktor - Neplechová, Kamila - Kašpárková, Jana - Farrell, Nicholas
PY - 2000
TI - Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups
JF - Journal of Biological Inorganic Chemistry
VL - 2000
IS - 5/3
SP - 364-368
EP - 364-368
PB - Springer Verlag
SN - 09498257
KW - DNA;cisplatin
KW - transplatin
KW - cross-link
KW - dimethyl sulfate
UR - http://link.springer.de/link/service/journals/00775/tocs/t0005003.htm
N2 - DNA binding studies of antitumor effective trans-platinum complexes with planar ligands have shown that they form much higher amount of interstrand cross-links than cisplatin. Interstrand cross-linking are formally equivalent to that of cisplatin but different from their direct ineffective analog, transplatin. This result shows that a simple chemical modification of the structure of inactive compound alters its DNA binding site into an addduct of active drug.
ER -
BRABEC, Viktor, Kamila NEPLECHOVÁ, Jana KAŠPÁRKOVÁ and Nicholas FARRELL. Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonlelaving groups. \textit{Journal of Biological Inorganic Chemistry}. Heidelberg: Springer Verlag, 2000, vol.~2000, 5/3, p.~364-368. ISSN~0949-8257.
|
