| HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ, Josef TOMANDL a Barbora RAVČUKOVÁ. Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder. Chemické listy. Praha: Česká spol. chemická, roč. 97 (S), červen, s. S180, 1 s. ISSN 0009-2770. 2003. |
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@article{489426,
author = {Hadašová, Eva and Žourková, Alexandra and Tomandl, Josef and Ravčuková, Barbora},
article_location = {Praha},
article_number = {červen},
keywords = {Genetic polymorphism; CYP2D6; paroxetine; alprazolam; psychiatric patients},
language = {eng},
issn = {0009-2770},
journal = {Chemické listy},
note = {Prezentováno na 13th International Conference on Cytochromes P450, Praha 2003},
title = {Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder},
volume = {97 (S)},
year = {2003}
}
TY - JOUR
ID - 489426
AU - Hadašová, Eva - Žourková, Alexandra - Tomandl, Josef - Ravčuková, Barbora
PY - 2003
TI - Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder
JF - Chemické listy
VL - 97 (S)
IS - červen
SP - S180
EP - S180
PB - Česká spol. chemická
SN - 00092770
N1 - Prezentováno na 13th International Conference on Cytochromes P450, Praha 2003
KW - Genetic polymorphism
KW - CYP2D6
KW - paroxetine
KW - alprazolam
KW - psychiatric patients
N2 - Dynamics of the paroxetine-induced inhibition of CYP2D6 was followed during the paroxetine therapy in patients using phenotyping and genotyping methods. Another aim of the study was to evaluate the level of the enzyme restoration after discontinuation of the paroxetine treatment. The study has shown that even a profound inhibition of CYP2D6 activity in patients without mutation in the CYP2D6 locus had only minor clinical relevance for treatment effectivity and occurence of adverse effects.
ER -
HADAŠOVÁ, Eva, Alexandra ŽOURKOVÁ, Josef TOMANDL a Barbora RAVČUKOVÁ. Dynamics of CYP2D6 activity and clinical response to paroxetine, alprazolam and their combination in patients with depressive disorder. \textit{Chemické listy}. Praha: Česká spol. chemická, roč.~97 (S), červen, s.~S180, 1 s. ISSN~0009-2770. 2003.
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