Rate dependent changes of action potential waveform in rat
ventricular myocytes. Action potential voltage clamp
experiments

D 2003

Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments

BÉBAROVÁ, Markéta; Peter MATEJOVIČ; Michal PÁSEK; Milena ŠIMURDOVÁ; Jiří ŠIMURDA et. al.

Základní údaje

Originální název

Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments

Autoři

BÉBAROVÁ, Markéta ; Peter MATEJOVIČ; Michal PÁSEK; Milena ŠIMURDOVÁ a Jiří ŠIMURDA

Vydání

Brno, Proceedings of symposium: Chronobiological analysis in pathophysiology of cardiovascular system, 7 s. 2003

Nakladatel

neuveden

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/03:00008624

Organizační jednotka

Lékařská fakulta

ISBN

80-7013-394-5

Klíčová slova anglicky

rate dependence; action potential; action potential voltage clamp; rat; ajmaline

Štítky

Action potential, action potential voltage clamp, ajmaline, rat, rate dependence

Příznaky

Mezinárodní význam

Změněno: 25. 4. 2011 20:59, doc. MUDr. Markéta Bébarová, Ph.D.

Anotace

ORIG CZ

V originále

Components of the total ionic current responsible for rate-dependent changes of action potential (AP) configuration were analyzed by the AP clamp method in isolated rat ventricular myocytes. The results demonstrate that besides Ca2+-mediated currents, cumulative inactivation of the transient outward current Ito significantly participates on the rate-dependent variability of AP configuration. Under the effect of antiarrhythmic drug ajmaline (30mikromol/l), the fast sodium current INa causes marked changes in the repolarization phase of AP, very likely as a consequence of its use-dependent block.

Česky

Byly analyzovány komponenty celkového iontového proudu zodpovědné za frekvenčně-závislé změny akčního napětí metodou vnuceného akčního napětí u izolovaných komorových srdečních buněk potkana.

Návaznosti

GP204/02/D129, projekt VaV

Název: Kvantitativní analýza vlivu tubulárního systému na elektrickou aktivitu srdečních buněk

Investor: Grantová agentura ČR, Kvantitativní analýza vlivu tubulárního systému na elektrickou aktivitu srdečních buněk

Citovat

BÉBAROVÁ, Markéta; Peter MATEJOVIČ; Michal PÁSEK; Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments. In Proceedings of symposium: Chronobiological analysis in pathophysiology of cardiovascular system. Brno: neuveden, 2003, 7 s. ISBN 80-7013-394-5.

@inproceedings{493026,
   author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Šimurdová, Milena and Šimurda, Jiří},
   address = {Brno},
   booktitle = {Proceedings of symposium: Chronobiological analysis in pathophysiology of cardiovascular system},
   keywords = {rate dependence; action potential; action potential voltage clamp; rat; ajmaline},
   language = {eng},
   location = {Brno},
   isbn = {80-7013-394-5},
   publisher = {neuveden},
   title = {Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments},
   year = {2003}
}

TY  - CONF
ID  - 493026
AU  - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Šimurdová, Milena - Šimurda, Jiří
PY  - 2003
TI  - Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments
PB  - neuveden
CY  - Brno
SN  - 8070133945
KW  - rate dependence
KW  - action potential
KW  - action potential voltage clamp
KW  - rat
KW  - ajmaline
N2  - Components of the total ionic current responsible for rate-dependent changes of action potential (AP) configuration were analyzed by the AP clamp method in isolated rat ventricular myocytes. The results demonstrate that besides Ca2+-mediated currents, cumulative inactivation of the transient outward current Ito significantly participates on the rate-dependent variability of AP configuration. Under the effect of antiarrhythmic drug ajmaline (30mikromol/l), the fast sodium current INa causes marked changes in the repolarization phase of AP, very likely as a consequence of its use-dependent block.
ER  -

BÉBAROVÁ, Markéta; Peter MATEJOVIČ; Michal PÁSEK; Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments. In \textit{Proceedings of symposium: Chronobiological analysis in pathophysiology of cardiovascular system}. Brno: neuveden, 2003, 7 s. ISBN~80-7013-394-5.

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