Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27

SCHWICKART, Martin; Jan HAVLIŠ; Bianca HABERMANN; Aliona BOGDANOVA; Alain CAMASSES; Tobias OELSCHLAEGEL; Andrej SHEVCHENKO a Wolfgang ZACHARIAE. Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27. Molecular and Cellular Biology. Washington, D.C.: ASM, 2004, roč. 24, č. 8, s. 3562-3576. ISSN 0270-7306.

Základní údaje

Originální název

Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27

Název anglicky

Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27

Autoři

SCHWICKART, Martin; Jan HAVLIŠ; Bianca HABERMANN; Aliona BOGDANOVA; Alain CAMASSES; Tobias OELSCHLAEGEL; Andrej SHEVCHENKO a Wolfgang ZACHARIAE

Vydání

Molecular and Cellular Biology, Washington, D.C. ASM, 2004, 0270-7306

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Další údaje

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 7.822

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000220685400044

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

Anglicky

The anaphase-promoting complex (APC/C) is a large ubiquitin-protein ligase which controls progression through anaphase by triggering the degradation of cell cycle regulators such as securin and B-type cyclins. The APC/C is an unusually complex ligase containing at least 10 different, evolutionarily conserved components. In contrast to APC/C's role in cell cycle regulation little is known about the functions of individual subunits and how they might interact with each other. Here, we have analyzed Swm1/Apc13, a small subunit recently identified in the budding yeast complex. Database searches revealed proteins related to Swm1/Apc13 in various organisms including humans. Both the human and the fission yeast homologues are associated with APC/C subunits, and they complement the phenotype of an SWM1 deletion mutant of budding yeast. Swm1/Apc13 promotes the stable association with the APC/C of the essential subunits Cdc16 and Cdc27. Accordingly, Swm1/Apc13 is required for ubiquitin ligase activity in vitro and for the timely execution of APC/C-dependent cell cycle events in vivo.