KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF
BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION

D 2004

KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION

SVOBODOVÁ, Ivona; Michaela MUDROVÁ; Přemysl LUBAL; Jan KOTEK; Petr HERMANN et. al.

Základní údaje

Originální název

KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION

Autoři

SVOBODOVÁ, Ivona; Michaela MUDROVÁ; Přemysl LUBAL; Jan KOTEK; Petr HERMANN; Josef HAVEL a Ivan LUKEŠ

Vydání

Athens, Book of Abstracts of Inorganic Reaction Mechanisms Meeting 2003, January 8-10, 2004, Athens, Greece, s. 10-10, 2004

Nakladatel

National and Kapodistrian University of Athens

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10406 Analytical chemistry

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES; copper(II) complexes; thermodynamics; kinetics

Štítky

BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES, copper(II) complexes, kinetics, Thermodynamics

Změněno: 31. 5. 2004 16:58, prof. RNDr. Přemysl Lubal, Ph.D.

Anotace

V originále

Complexes of Cu(II) with macrocyclic ligands are utilized as bifunctional chelating agents in nuclear medicine, e.g. in radioisotope diagnostics (64Cu) or in tumor radiotherapy (67Cu). There is necessity to know thermodynamic and kinetic properties (formation and dissociation rate constants) of copper and other biometal ion complexes under experimental conditions similar to body fluids for possible medical application in vivo. In this work, the formation kinetics of copper(II) complexes of macrocyclic ligands with phosphonic acid pendant arms was studied (dipon, L1, Me2dipon, L2, dipon-diester, L3) (t = 25 oC, I = 0.1 M). The reactivity decreases in order L1 > L2 > L3. The copper(II) complex of L1 ligand can be found in two isomeric forms. They differ in the number of bound donor atoms and cyclam skeleton arrangement. The mechanism of isomerisation reaction was studied in different media (aqueous ammonia, water) by means of different experimental techniques and catalysis of reaction by ammonia was observed. The dissociation kinetics of copper(II) complexes of L1 and L2 macrocyclic ligands was investigated under extreme experimental conditions (t = 25-65 oC, I = 5 M (Na,H)ClO4). The acid-assisted dissociation of complexes is faster for [Cu(H2L2)] than for [Cu(H2L1)] compounds. In case [Cu(H2L1)], both isomeric species demonstrate a high kinetic inertness in presence of 5 M perchloric acid (t = 25 oC, Tau1/2 = 20 min and 6.7 months for penta- and hexacoordinated isomers, respectively).

Návaznosti

GA203/02/0493, projekt VaV

Název: Bifunkční cheláty. Syntéza a komplexotvorné vlastnosti

Investor: Grantová agentura ČR, Bifunkční cheláty. Syntéza a komplexotvorné vlastnosti

GA203/03/0168, projekt VaV

Název: Kineticky inertní komplexy iontů přechodných kovů a lanthanoidů. Design, syntéza a kinetická studia

MSM 143100011, záměr

Název: Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů

Citovat

SVOBODOVÁ, Ivona; Michaela MUDROVÁ; Přemysl LUBAL; Jan KOTEK; Petr HERMANN; Josef HAVEL a Ivan LUKEŠ. KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION. In Book of Abstracts of Inorganic Reaction Mechanisms Meeting 2003, January 8-10, 2004, Athens, Greece. Athens: National and Kapodistrian University of Athens, 2004, s. 10.

@inproceedings{555469,
   author = {Svobodová, Ivona and Mudrová, Michaela and Lubal, Přemysl and Kotek, Jan and Hermann, Petr and Havel, Josef and Lukeš, Ivan},
   address = {Athens},
   booktitle = {Book of Abstracts of Inorganic Reaction Mechanisms Meeting 2003, January 8-10, 2004, Athens, Greece},
   keywords = {BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES; copper(II) complexes; thermodynamics; kinetics},
   language = {eng},
   location = {Athens},
   pages = {10-10},
   publisher = {National and Kapodistrian University of Athens},
   title = {KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION},
   year = {2004}
}

TY  - CONF
ID  - 555469
AU  - Svobodová, Ivona - Mudrová, Michaela - Lubal, Přemysl - Kotek, Jan - Hermann, Petr - Havel, Josef - Lukeš, Ivan
PY  - 2004
TI  - KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION
PB  - National and Kapodistrian University of Athens
CY  - Athens
KW  - BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES
KW  - copper(II) complexes
KW  - thermodynamics
KW  - kinetics
N2  - Complexes of Cu(II) with macrocyclic ligands are utilized as bifunctional chelating agents in nuclear medicine, e.g. in radioisotope diagnostics (64Cu) or in tumor radiotherapy (67Cu). There is necessity to know thermodynamic and kinetic properties (formation and dissociation rate constants) of copper and other biometal ion complexes under experimental conditions similar to body fluids for possible medical application in vivo. In this work, the formation kinetics of copper(II) complexes of macrocyclic ligands with phosphonic acid pendant arms was studied (dipon, L1, Me2dipon, L2, dipon-diester, L3) (t = 25 oC, I = 0.1 M). The reactivity decreases in order L1 > L2 > L3. The copper(II) complex of L1 ligand can be found in two isomeric forms. They differ in the number of bound donor atoms and cyclam skeleton arrangement. The mechanism of isomerisation reaction was studied in different media (aqueous ammonia, water) by means of different experimental techniques and catalysis of reaction by ammonia was observed. The dissociation kinetics of copper(II) complexes of L1 and L2 macrocyclic ligands was investigated under extreme experimental conditions (t = 25-65 oC, I = 5 M (Na,H)ClO4). The acid-assisted dissociation of complexes is faster for [Cu(H2L2)] than for [Cu(H2L1)] compounds. In case [Cu(H2L1)], both isomeric species demonstrate a high kinetic inertness in presence of 5 M perchloric acid (t = 25 oC, Tau1/2 = 20 min and 6.7 months for penta- and hexacoordinated isomers, respectively).
ER  -

SVOBODOVÁ, Ivona; Michaela MUDROVÁ; Přemysl LUBAL; Jan KOTEK; Petr HERMANN; Josef HAVEL a Ivan LUKEŠ. KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION. In \textit{Book of Abstracts of Inorganic Reaction Mechanisms Meeting 2003, January 8-10, 2004, Athens, Greece}. Athens: National and Kapodistrian University of Athens, 2004, s.~10.

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