Interaction of Plant Polyphenols with Iron Ions

D 2004

Interaction of Plant Polyphenols with Iron Ions

CHVÁTALOVÁ, Kateřina a Jiří SLANINA

Základní údaje

Originální název

Interaction of Plant Polyphenols with Iron Ions

Název česky

Interakce rostlinných polyfenolů s ionty železa

Autoři

CHVÁTALOVÁ, Kateřina a Jiří SLANINA

Vydání

Pardubice, Vitamins 2004 - Targeted Nutritional Therapy, od s. 168-168, 1 s. 2004

Nakladatel

Univerzita Pardubice

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/04:00011718

Organizační jednotka

Lékařská fakulta

ISBN

80-7194-644-3

Klíčová slova anglicky

polyphenols; iron ions; ferrozin

Štítky

ferrozin, Iron ions, Polyphenols

Změněno: 31. 5. 2005 12:16, Mgr. Jiří Slanina, Ph.D.

Anotace

ORIG CZ

V originále

Polyphenols are plant secondary metabolites that are a common part of human diet. Some epidemiological studies have suggested an association between the consumption of polyphenol-rich foods or beverages and the prevention of cardiovascular diseases and cancer. These pathological conditions are connected with excessive free radicals production. Formation of free radicals is closely related to the redox state of iron, e.g. ferrous ions are responsible for hydroxyl radical formation by Fenton reaction. Numerous authors have investigated the free radical scavenging activity of plant polyphenols, and several reports have been made to elucidated iron or copper ions chelating ability of polyphenols, although the interaction of plant polyphenols with transient metal ions has not been fully resolved. In this study we investigated the formation of Fe2+ and Fe3+ complexes with naturally occurring polyphenolic compounds above all phenolic acids by spectrophotometric measurement at pH 7.4. The stability of complexes was evaluated after addition of EDTA and ascorbic acid. Influence of ligands on Fe2+ autooxidation and Fe3+ reducing activity of polyphenols was assessed by determination of Fe2+ concentration using ferrozine. Interaction of polyphenolic compounds with iron was compared with that of ascorbic acid and cysteine. Both ascorbic acid and cysteine inhibited Fe2+ autooxidation and reduced ferric ions, and thus tend to stabilize Fe2+ ions. Conversely, most of polyphenolic compounds showed little or no reducing activity on Fe3+ ions and effectively increased the rate of Fe2+ autooxidation. Analyses of interaction of plant polyphenols with iron may be useful for elucidation of their antioxidant effect.

Česky

Vznik volných radikálů je těsně spojen s redoxním stavem železa, např. železnaté ionty jsou zodpovědné za vznik hydroxylových radikálů Fentonovou reakcí.

Návaznosti

GA303/00/D062, projekt VaV

Název: Biologická dostupnost a mechanismus antioxidačního účinku fenolických kyselin a lignanů

Investor: Grantová agentura ČR, Biologická dostupnost a mechanismus antioxidačního účinku fenolických kyselin a lignanů

Citovat

CHVÁTALOVÁ, Kateřina a Jiří SLANINA. Interaction of Plant Polyphenols with Iron Ions. In Vitamins 2004 - Targeted Nutritional Therapy. Pardubice: Univerzita Pardubice, 2004, s. 168-168. ISBN 80-7194-644-3.

@inproceedings{561961,
   author = {Chvátalová, Kateřina and Slanina, Jiří},
   address = {Pardubice},
   booktitle = {Vitamins 2004 - Targeted Nutritional Therapy},
   keywords = {polyphenols; iron ions; ferrozin},
   language = {eng},
   location = {Pardubice},
   isbn = {80-7194-644-3},
   pages = {168-168},
   publisher = {Univerzita Pardubice},
   title = {Interaction of Plant Polyphenols with Iron Ions},
   year = {2004}
}

TY  - CONF
ID  - 561961
AU  - Chvátalová, Kateřina - Slanina, Jiří
PY  - 2004
TI  - Interaction of Plant Polyphenols with Iron Ions
PB  - Univerzita Pardubice
CY  - Pardubice
SN  - 8071946443
KW  - polyphenols
KW  - iron ions
KW  - ferrozin
N2  - Polyphenols are plant secondary metabolites that are a common part of human diet. Some epidemiological studies have suggested an association between the consumption of polyphenol-rich foods or beverages and the prevention of cardiovascular diseases and cancer. These pathological conditions are connected with excessive free radicals production. Formation of free radicals is closely related to the redox state of iron, e.g. ferrous ions are responsible for hydroxyl radical formation by Fenton reaction. Numerous authors have investigated the free radical scavenging activity of plant polyphenols, and several reports have been made to elucidated iron or copper ions chelating ability of polyphenols, although the interaction of plant polyphenols with transient metal ions has not been fully resolved. In this study we investigated the formation of Fe2+ and Fe3+ complexes with naturally occurring polyphenolic compounds above all phenolic acids by spectrophotometric measurement at pH 7.4. The stability of complexes was evaluated after addition of EDTA and ascorbic acid. Influence of ligands on Fe2+ autooxidation and Fe3+ reducing activity of polyphenols was assessed by determination of Fe2+ concentration using ferrozine. Interaction of polyphenolic compounds with iron was compared with that of ascorbic acid and cysteine. Both ascorbic acid and cysteine inhibited Fe2+ autooxidation and reduced ferric ions, and thus tend to stabilize Fe2+ ions. Conversely, most of polyphenolic compounds showed little or no reducing activity on Fe3+ ions and effectively increased the rate of Fe2+ autooxidation. Analyses of interaction of plant polyphenols with iron may be useful for elucidation of their antioxidant effect.
ER  -

CHVÁTALOVÁ, Kateřina a Jiří SLANINA. Interaction of Plant Polyphenols with Iron Ions. In \textit{Vitamins 2004 - Targeted Nutritional Therapy}. Pardubice: Univerzita Pardubice, 2004, s.~168-168. ISBN~80-7194-644-3.

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