| NOVÁKOVÁ, Jana, Jana PISTOVČÁKOVÁ, Jana VINKLEROVÁ a Alexandra ŠULCOVÁ. Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy. Fundamental & Clinical Pharmacology. UK: Blackwell Publishing, roč. 18, Suppl. 1, s. 45-45. ISSN 1744-3377. 2004. |
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@article{562912,
author = {Nováková, Jana and Pistovčáková, Jana and Vinklerová, Jana and Šulcová, Alexandra},
article_location = {UK},
article_number = {Suppl. 1},
keywords = {rats; 5-HT1 and 5-HT2 receptor ligands; methamphetamine; dependence; depression},
language = {eng},
issn = {1744-3377},
journal = {Fundamental & Clinical Pharmacology},
title = {Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy},
volume = {18},
year = {2004}
}
TY - JOUR
ID - 562912
AU - Nováková, Jana - Pistovčáková, Jana - Vinklerová, Jana - Šulcová, Alexandra
PY - 2004
TI - Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy
JF - Fundamental & Clinical Pharmacology
VL - 18
IS - Suppl. 1
SP - 45-45
EP - 45-45
PB - Blackwell Publishing
SN - 17443377
KW - rats
KW - 5-HT1 and 5-HT2 receptor ligands
KW - methamphetamine
KW - dependence
KW - depression
N2 - The influence of 5-HT1 and 5-HT2 receptor antagonists on methamphetamine intake was analysed in both, naive rats and those depressed by olfactory bulbectomy. Our results indicate that the involvement of 5-HT2 rather than 5-HT1 receptor is important for methamphetamine reward properties what corresponds with the outcomes of methamphetamine discriminative studies. Thus, 5-HT2 receptor antagonists referred to attenuate the withdrawal signs of drugs of abuse could be of benefit also in treatment of methamphetamine dependence, mainly in addicts with depressive disorders.
ER -
NOVÁKOVÁ, Jana, Jana PISTOVČÁKOVÁ, Jana VINKLEROVÁ a Alexandra ŠULCOVÁ. Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy. \textit{Fundamental \&{} Clinical Pharmacology}. UK: Blackwell Publishing, roč.~18, Suppl. 1, s.~45-45. ISSN~1744-3377. 2004.
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