Detailed Information on Publication Record
2005
PREDICTIVE PARAMETERS OF THE PHARYNX AND SUPRAGLOTTIC CARCINOMAS
SMILEK, Pavel, Rom KOSTŘICA, Jan ROTTENBERG, Karel VESELÝ, Ladislav DUŠEK et. al.Basic information
Original name
PREDICTIVE PARAMETERS OF THE PHARYNX AND SUPRAGLOTTIC CARCINOMAS
Name in Czech
Prediktivní parametry karcinomu faryngu a supraglottis
Name (in English)
PREDICTIVE PARAMETERS OF THE PHARYNX AND SUPRAGLOTTIC CARCINOMAS
Authors
SMILEK, Pavel, Rom KOSTŘICA, Jan ROTTENBERG, Karel VESELÝ and Ladislav DUŠEK
Edition
Brno, Sborník abstrakt a program 68. kongresu České spol. pro otorinolaryngologii a chir. hlavy a krku, p. 111-111, 2005
Publisher
Medica Publishing and consulting s.r.o.
Other information
Language
Czech
Type of outcome
Stať ve sborníku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Organization unit
Faculty of Medicine
ISBN
80-239-5112-2
Keywords in English
head and neck cancer; prognosis; p53; DNA flow-cytometry
Změněno: 22/6/2005 08:16, doc. MUDr. Pavel Smilek, Ph.D.
V originále
The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis. Besides routine examinations, flow cytometric analysis of was performed, p53 and Ki-67 markers were established by means of immunohistochemistry. Furthermore mitotic and apoptotic index were established. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Early progressed cases have typically decreased SPF fraction combined with increased mitotic activity.
In English
The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis. Besides routine examinations, flow cytometric analysis of was performed, p53 and Ki-67 markers were established by means of immunohistochemistry. Furthermore mitotic and apoptotic index were established. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Early progressed cases have typically decreased SPF fraction combined with increased mitotic activity.