Age related changes of baroreflex sensitivity in children and adolescents

ZÁVODNÁ, Eva, Hana HRSTKOVÁ, Zuzana NOVÁKOVÁ, Bohumil FIŠER a Nataša HONZÍKOVÁ. Age related changes of baroreflex sensitivity in children and adolescents. In 14th Meeting of Paediatric Research of Cenral European Countries. 2005.

Základní údaje

• Originální název: Age related changes of baroreflex sensitivity in children and adolescents
• Název česky: Na věku závislé změny baroreflexní citlivosti u dětí a dospívajících
• Název anglicky: Age related changes of baroreflex sensitivity in children and adolescents
• Autoři: ZÁVODNÁ, Eva (203 Česká republika, garant), Hana HRSTKOVÁ (203 Česká republika), Zuzana NOVÁKOVÁ (203 Česká republika), Bohumil FIŠER (203 Česká republika) a Nataša HONZÍKOVÁ (203 Česká republika).
• Vydání: 14th Meeting of Paediatric Research of Cenral European Countries, 2005.

Další údaje

• Originální jazyk: čeština
• Typ výsledku: Konferenční abstrakt
• Obor: 30105 Physiology
• Stát vydavatele: Česká republika
• Utajení: není předmětem státního či obchodního tajemství
• Kód RIV: RIV/00216224:14110/05:00013798
• Organizační jednotka: Lékařská fakulta
• Klíčová slova anglicky: baroreflex sensitivity; developemnt; children; adolescents
• Štítky: Adolescents, baroreflex sensitivity, children, developemnt

Anotace

The aim of the study was to investigate the development of noninvasively determined baroreflex sensitivity in age between 11 to 18 years. Continuous 5 min blood pressure readings were recorded in 332 healthy subjects. Beat-to-beat values of inter beat intervals (IBI), systolic blood pressures (SBP) were measured. Baroreflex sensitivity in ms/mmHg (BRS) and in mHz/mmHg (BRSf) was determined by spectral analysis. BRS did not correlate with age, BRSf significantly decrease with age (p<0.001). BRS correlated with mean IBI (p<0.001), but BRSf was IBI-independent. Multiregression analysis showed significant decrease of BRS with age after standardization to IBI. The limits of BRS were estimated for the whole group: 5th percentile - 3.9 ms/mmHg; 50th - 9.1; 95th - 18.9. BRS was unchanged in particular age groups, but it was dependent on IBI. Standardization of BRS on IBI disclosed its decrease with age. BRSf is IBI-independent and better reflects the development of baroreflex sensitivity with age.

Anotace anglicky

The aim of the study was to investigate the development of noninvasively determined baroreflex sensitivity in age between 11 to 18 years. Continuous 5 min blood pressure readings were recorded in 332 healthy subjects. Beat-to-beat values of inter beat intervals (IBI), systolic blood pressures (SBP) were measured. Baroreflex sensitivity in ms/mmHg (BRS) and in mHz/mmHg (BRSf) was determined by spectral analysis. BRS did not correlate with age, BRSf significantly decrease with age (p<0.001). BRS correlated with mean IBI (p<0.001), but BRSf was IBI-independent. Multiregression analysis showed significant decrease of BRS with age after standardization to IBI. The limits of BRS were estimated for the whole group: 5th percentile - 3.9 ms/mmHg; 50th - 9.1; 95th - 18.9. BRS was unchanged in particular age groups, but it was dependent on IBI. Standardization of BRS on IBI disclosed its decrease with age. BRSf is IBI-independent and better reflects the development of baroreflex sensitivity with age.

Návaznosti

• MSM0021622402, záměr: Název: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Časná diagnostika a léčba kardiovaskulárních chorob

• NR8006, projekt VaV: Název: Autonomní oběhové funkce, funkce myokardu a kardiorespirační funkce u dětí a adolescentů po léčbě zhoubného nádoru

Investor: Ministerstvo zdravotnictví ČR, Autonomní oběhové funkce, funkce myokardu a kardiorespirační funkce u dětí a adolescentů po léčbě zhoubného nádoru