Feet of methamphetamine on pharmacokinetics of dextromethorphan
and midazolam in rats.

J 2005

Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats.

DOSTÁLEK, Miroslav; Eva HADAŠOVÁ; Mariana HANESOVÁ; Jana PISTOVČÁKOVÁ; Alexandra ŠULCOVÁ et. al.

Základní údaje

Originální název

Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats.

Název česky

Vliv metamfetaminu na farmakokinetiku dextrometorfanu a midazolamu.

Autoři

DOSTÁLEK, Miroslav; Eva HADAŠOVÁ; Mariana HANESOVÁ; Jana PISTOVČÁKOVÁ; Alexandra ŠULCOVÁ; Jan JUŘICA; Josef TOMANDL a Igor LINHART

Vydání

Eur J Drug Metab Pharmacokinet, Switzerland, Medicne et Hygiena, 2005, 0378-7966

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.585

Kód RIV

RIV/00216224:14110/05:00014064

Organizační jednotka

Lékařská fakulta

UT WoS

000232621200008

Klíčová slova anglicky

Midazolam; Methamphetamine; Cytochrome P-450; CYP3A1/2 isozyme

Štítky

CYP3A1/2 isozyme, cytochrome P-450, methamphetamine, midazolam

Změněno: 6. 6. 2012 08:38, doc. RNDr. Josef Tomandl, Ph.D.

Anotace

ORIG CZ

V originále

Methamphetamine is the fourth most frequently cited drug of abuse on treatment centre admission records behind cocaine, heroin and marijuana. We investigated the effect of methamphetamine (10 mg/kg, i.p., once daily for six days) on the pharmacokinetics of midazolam a substrate for rat cytochrome P-450 3A. Animals received a single injection of midazolam (5 mg/kg) in tail vein 24 h after the last dose of methamphetamine and placebo. Validated HPLC method was used to quantify all compounds of interest. The elimination half-life (t1/2) and the area under the concentration-time curve of midazolam were significantly reduced by pretreatment with methamphetamine to 63.8 % and 66.3 of control value, respectively and the clearance of midazolam was significantly increased by methamphetamine pretreatment. The results showed that administration of methamphetamine significantly stimulated metabolic activity of CYP3A1/2. With regard to a high level of homology between human and rat CYP isoforms studied, the results may have clinical impact in pharmacotherapy of methamphetamine abusers.

Česky

Cílem studie bylo popsat vliv opakovaného podávání metamfetaminu (10 mg/ kg, i.p., jednou denně po dobu 6ti dnů) na farmakokinetické parametry dextrometorfanu (markeru metabolické aktivity CYP2D2) a midazolamu (markeru metabolické aktivity CYP3A1/2). Poločas eliminace midazolamu a plocha pod koncentrační křivkou midazolamu byly opakovaným podáváním metamfetaminu statisticky významně zkráceny na 63.8 % resp. 66.3 % hodnoty kontrolní skupiny. Clearance midazolamu byla metamfetaminem statisticky významně zvýšena. Metamfetamin statisticky významně zvýšil aktivitu formy CYP3A1/2 a díky velké podobnosti potkaní a lidské formy se zjistěné výsledky mohou stát významné pro klinickou praxi.

Návaznosti

MSM 141100001, záměr

Název: Plasticita řídících systémů centrálního nervového systému a možnosti jejího ovlivnění

Citovat

DOSTÁLEK, Miroslav; Eva HADAŠOVÁ; Mariana HANESOVÁ; Jana PISTOVČÁKOVÁ; Alexandra ŠULCOVÁ; Jan JUŘICA; Josef TOMANDL a Igor LINHART. Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats. Eur J Drug Metab Pharmacokinet. Switzerland,: Medicne et Hygiena, 2005, roč. 30, č. 3, s. 195-201. ISSN 0378-7966.

@article{584841,
   author = {Dostálek, Miroslav and Hadašová, Eva and Hanesová, Mariana and Pistovčáková, Jana and Šulcová, Alexandra and Juřica, Jan and Tomandl, Josef and Linhart, Igor},
   article_location = {Switzerland,},
   article_number = {3},
   keywords = {Midazolam; Methamphetamine; Cytochrome P-450; CYP3A1/2 isozyme},
   language = {eng},
   issn = {0378-7966},
   journal = {Eur J Drug Metab Pharmacokinet},
   title = {Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats.},
   volume = {30},
   year = {2005}
}

TY  - JOUR
ID  - 584841
AU  - Dostálek, Miroslav - Hadašová, Eva - Hanesová, Mariana - Pistovčáková, Jana - Šulcová, Alexandra - Juřica, Jan - Tomandl, Josef - Linhart, Igor
PY  - 2005
TI  - Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats.
JF  - Eur J Drug Metab Pharmacokinet
VL  - 30
IS  - 3
SP  - 195-201
EP  - 195-201
PB  - Medicne et Hygiena
SN  - 03787966
KW  - Midazolam
KW  - Methamphetamine
KW  - Cytochrome P-450
KW  - CYP3A1/2 isozyme
N2  - Methamphetamine is the fourth most frequently cited drug of abuse on treatment centre admission records behind cocaine, heroin and marijuana. We investigated the effect of methamphetamine (10 mg/kg, i.p., once daily for six days) on the pharmacokinetics of midazolam a substrate for rat cytochrome P-450 3A. Animals received a single injection of midazolam (5 mg/kg) in tail vein 24 h after the last dose of methamphetamine and placebo. Validated HPLC method was used to quantify all compounds of interest. The elimination half-life (t1/2) and the area under the concentration-time curve of midazolam were significantly reduced by pretreatment with methamphetamine to 63.8 % and 66.3 of control value, respectively and the clearance of midazolam was significantly increased by methamphetamine pretreatment. The results showed that administration of methamphetamine significantly stimulated metabolic activity of CYP3A1/2. With regard to a high level of homology between human and rat CYP isoforms studied, the results may have clinical impact in pharmacotherapy of methamphetamine abusers.
ER  -

DOSTÁLEK, Miroslav; Eva HADAŠOVÁ; Mariana HANESOVÁ; Jana PISTOVČÁKOVÁ; Alexandra ŠULCOVÁ; Jan JUŘICA; Josef TOMANDL a Igor LINHART. Feet of methamphetamine on pharmacokinetics of dextromethorphan and midazolam in rats. \textit{Eur J Drug Metab Pharmacokinet}. Switzerland,: Medicne et Hygiena, 2005, roč.~30, č.~3, s.~195-201. ISSN~0378-7966.

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