KREJCI, Lumir, Julia ETCHIN, San Joe FILIPPO a Patrick SUNG. DNA Binding and Strand Annealing Properties of the Human BRCA2 DNA Binding Domain. In Era of Hope 2005 - Department of Defense Breast Cancer Research Program Meeting. Philadelphia, USA: U.S. Army Medical Research and Materiel Command, 2005. 89 s.
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Základní údaje
Originální název DNA Binding and Strand Annealing Properties of the Human BRCA2 DNA Binding Domain
Název česky DNA vazebné a hybridizacní vlastnosti DNA vazebne doménz lidského BRCA2 proteinu
Autoři KREJCI, Lumir, Julia ETCHIN, San Joe FILIPPO a Patrick SUNG.
Vydání Philadelphia, USA, Era of Hope 2005 - Department of Defense Breast Cancer Research Program Meeting, 89 s. 2005.
Nakladatel U.S. Army Medical Research and Materiel Command
Další údaje
Originální jazyk angličtina
Typ výsledku Stať ve sborníku
Obor 1.6 Biological sciences
Stát vydavatele Spojené státy americké
Utajení není předmětem státního či obchodního tajemství
WWW URL
Organizační jednotka Přírodovědecká fakulta
Klíčová slova anglicky DNA repair; recombination; breast cancer; BRCA2; DNA binding
Štítky BRCA2, breast cancer, DNA binding, DNA repair, recombination
Změnil Změnil: doc. Mgr. Lumír Krejčí, Ph.D., učo 18098. Změněno: 30. 6. 2009 22:43.
Anotace
Mutations in the BRCA2 (breast cancer susceptibility gene 2) gene give rise to a significant portion of familial breast cancers. BRCA2 associates with Rad51, a key member of the RAD52 group, through a series of conserved modules called BRC repeats. Rad51 has a recombinase activity that mediates the formation of DNA joints between the injured chromosome and an intact homologue during HR. In mediating HR reactions, Rad51 nucleates onto single-stranded (ss) DNA derived from lesion processing to form a highly ordered nucleoprotein filament structure, often referred to as the presynaptic filament. After locating a DNA homologue, the presynaptic filament catalyzes pairing with the homologue to form a nascent DNA joint called a D-loop, the length of which is extended by DNA strand exchange. Concurrently, DNA synthesis commences to replace the genetic information lost during the lesion processing step. Subsequent steps include resolution of recombination intermediates and ligation to complete the recombination/repair reaction.
Anotace česky
Mutations in the BRCA2 (breast cancer susceptibility gene 2) gene give rise to a significant portion of familial breast cancers. BRCA2 associates with Rad51, a key member of the RAD52 group, through a series of conserved modules called BRC repeats. Rad51 has a recombinase activity that mediates the formation of DNA joints between the injured chromosome and an intact homologue during HR. In mediating HR reactions, Rad51 nucleates onto single-stranded (ss) DNA derived from lesion processing to form a highly ordered nucleoprotein filament structure, often referred to as the presynaptic filament. After locating a DNA homologue, the presynaptic filament catalyzes pairing with the homologue to form a nascent DNA joint called a D-loop, the length of which is extended by DNA strand exchange. Concurrently, DNA synthesis commences to replace the genetic information lost during the lesion processing step. Subsequent steps include resolution of recombination intermediates and ligation to complete the recombination/repair reaction.
Návaznosti
MSM0021622413, záměrNázev: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumné záměry
VytisknoutZobrazeno: 16. 10. 2019 12:35