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@article{611504,
author = {Bryja, V. and Pacherník, J. and Faldíková, L. and Krejčí, P. and Pogue, R. and Nevřivá, I. and Dvořák, P. and Hampl, Aleš},
article_number = {2-3},
keywords = {cells},
language = {eng},
issn = {0006-3002},
journal = {Biochimica et Biophysica Acta},
title = {The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo},
volume = {1691},
year = {2004}
}
TY - JOUR
ID - 611504
AU - Bryja, V. - Pacherník, J. - Faldíková, L. - Krejčí, P. - Pogue, R. - Nevřivá, I. - Dvořák, P. - Hampl, Aleš
PY - 2004
TI - The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo
JF - Biochimica et Biophysica Acta
VL - 1691
IS - 2-3
SP - 105-116
EP - 105-116
SN - 00063002
KW - cells
N2 - This in vivo study employs p27-deficient mice to investigate the significance of p27 for the metabolism of D-type cyclins in differentiated cells. The absence of p27 results in decreased levels of cyclins D2 and/or D3 in some organs. As demonstrated on Leydig cells of testis, such dependency is only restricted to certain cell types including terminally differentiated ones, and the absence of p27 in these cells can interfere with their differentiation. The decrease of cyclin D caused by the absence of p27 equals the amount of cyclin D physically associated with p27 in non-mutant animals. The data indicate that it is the proportion of p27-associated cyclin D that determines the response to p27 deficiency. Cells in which the level of D-type cyclin is dependent on p27 do not up-regulate the activity of their CDK2 and CDK4 upon loss of p27, and these cells have a negligible amount of p27 bound to CDK2 and/or cyclin A/E under normal conditions. Together, the findings suggest the existence of a dual role for p27, one being a classical regulation of cell cycle via inhibition of cyclin-dependent kinases (CDK), and the other being participation in the establishment and/or maintenance of differentiated status that is realized in conjunction with D-type cyclins.
ER -
BRYJA, V., J. PACHERNÍK, L. FALDÍKOVÁ, P. KREJČÍ, R. POGUE, I. NEVŘIVÁ, P. DVOŘÁK a Aleš HAMPL. The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo. \textit{Biochimica et Biophysica Acta}. 2004, roč.~1691, 2-3, s.~105-116. ISSN~0006-3002.
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