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@article{692352,
author = {Vlková, Marcela and Thon, Vojtěch and Šárfyová, Mária and Bláha, Luděk and Svobodník, Adam and Lokaj, Jindřich and Litzman, Jiří},
article_number = {2},
keywords = {Common variable immunodeficiency; T-lymphocyte subsets; B-lymphocyte subsets; differentiation antigens; age factor},
language = {eng},
issn = {0009-9104},
journal = {Clin Exp Immunol},
title = {Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients},
volume = {143},
year = {2006}
}
TY - JOUR
ID - 692352
AU - Vlková, Marcela - Thon, Vojtěch - Šárfyová, Mária - Bláha, Luděk - Svobodník, Adam - Lokaj, Jindřich - Litzman, Jiří
PY - 2006
TI - Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients
JF - Clin Exp Immunol
VL - 143
IS - 2
SP - 373-379
EP - 373-379
PB - Blaskwell Synergy
SN - 00099104
KW - Common variable immunodeficiency
KW - T-lymphocyte subsets
KW - B-lymphocyte subsets
KW - differentiation antigens
KW - age factor
N2 - Common variable immunodeficiency (CVID) is primary hypogammaglobulinemia with unknown etiopathogenesis. Although various abnormalities of T- and B-cells were described, their pathogenetic roles are unclear. Markers associated with B-cell development were determined on B-lymphocytes (CD19+); T-lymphocyte development and activations markers were determined on CD4+ and CD8+ T-lymphocytes in 42 CVID patients and in 33 healthy controls. Abnormalities in CD4+ T-lymphocyte activation markers (increase in CD29, HLA-DR, CD45RO, decrease in CD27, CD62L, CD45RA) were particularly observed in patients with a decreased number of memory (CD27+) and mature (CD21+) B-cells (group Ia according to Freiburg classification), while abnormalities observed in CD8+ cells (increase in CD27 and CD28 and decrease in HLA-DR, CD57 and CD38) did not depend on grouping patients together according to B-lymphocyte developmental subpopulations. The expression of CD27 and CD45RA on CD4+ T-lymphocytes, such as the percentage of IgD+CD27- and IgD+CD27+ cells in B-lymphocytes, showed age dependency to be more significant than in the control group.
ER -
VLKOVÁ, Marcela, Vojtěch THON, Mária ŠÁRFYOVÁ, Luděk BLÁHA, Adam SVOBODNÍK, Jindřich LOKAJ a Jiří LITZMAN. Age dependency and mutual relations in T- and B- lymphocyte abnormalities in CVID patients. \textit{Clin Exp Immunol}. Blaskwell Synergy, 2006, roč.~143, č.~2, s.~373-379. ISSN~0009-9104.
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