Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor
(TIMP-1) in relation to pro- and anti-fibrotic factors in
patients with heart failure

D 2006

Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure

TOMANDL, Josef; Hana PAULOVÁ; Lenka ŠPINAROVÁ; Eva TÁBORSKÁ; Jindřich ŠPINAR et al.

Základní údaje

Originální název

Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure

Název česky

Sérová matrix metalloproteinasa (MMP-2) a její tkáňový inhibitor (TIMP-1) ve vztahu k pro- a anti-fibrotickým faktorům u pacientů se srdečním selháním

Autoři

TOMANDL, Josef ; Hana PAULOVÁ; Lenka ŠPINAROVÁ; Eva TÁBORSKÁ a Jindřich ŠPINAR

Vydání

Bratislava, Proceedings from XX. Biochemický zjazd, s. 358-358, 2006

Nakladatel

Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/06:00017183

Organizační jednotka

Lékařská fakulta

ISBN

80-969532-6-5

Klíčová slova anglicky

metalloproteinase - tissue inhibitor - fibrotic factors - heart failure

Změněno: 18. 9. 2006 16:26, doc. RNDr. Josef Tomandl, Ph.D.

Anotace

ORIG CZ

V originále

Matrix metalloproteinase MMP-2 and its endogenous inhibitor TIMP-1 are associated with extracellular matrix remodeling, which may lead to interstitial fibrosis and thus contribute to heart failure. Besides, pro- and anti-fibrotic factors such as endothelin-1 and nitric oxide, respectively, regulate fibrosis by modulating collagen synthesis and also MMP/TIMP activity. Nowadays, there is thought that progressive remodeling accompanied with changes in the extracellular matrix may lead to severe heart failure. The aim of this study was to find a relationship between MMP-2/TIMP-1 and other above mentioned parameters in patients with heart failure.

Česky

Návaznosti

MSM0021622402, záměr

Název: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Časná diagnostika a léčba kardiovaskulárních chorob

Citovat

TOMANDL, Josef; Hana PAULOVÁ; Lenka ŠPINAROVÁ; Eva TÁBORSKÁ a Jindřich ŠPINAR. Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure. In Proceedings from XX. Biochemický zjazd. Bratislava: Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, 2006, s. 358. ISBN 80-969532-6-5.

@inproceedings{695827,
   author = {Tomandl, Josef and Paulová, Hana and Špinarová, Lenka and Táborská, Eva and Špinar, Jindřich},
   address = {Bratislava},
   booktitle = {Proceedings from XX. Biochemický zjazd},
   keywords = {metalloproteinase - tissue inhibitor - fibrotic factors - heart failure},
   language = {eng},
   location = {Bratislava},
   isbn = {80-969532-6-5},
   note = {XX. Biochemický zjazd},
   pages = {358-358},
   publisher = {Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences},
   title = {Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure},
   year = {2006}
}

TY  - CONF
ID  - 695827
AU  - Tomandl, Josef - Paulová, Hana - Špinarová, Lenka - Táborská, Eva - Špinar, Jindřich
PY  - 2006
TI  - Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure
PB  - Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences
CY  - Bratislava
SN  - 8096953265
N1  - XX. Biochemický zjazd
KW  - metalloproteinase - tissue inhibitor - fibrotic factors - heart failure
N2  - Matrix metalloproteinase MMP-2 and its endogenous inhibitor TIMP-1 are associated with extracellular matrix remodeling, which may lead to interstitial fibrosis and thus contribute to heart failure. Besides, pro- and anti-fibrotic factors such as endothelin-1 and nitric oxide, respectively, regulate fibrosis by modulating collagen synthesis and also MMP/TIMP activity. Nowadays, there is thought that progressive remodeling accompanied with changes in the extracellular matrix may lead to severe heart failure. The aim of this study was to find a relationship between MMP-2/TIMP-1 and other above mentioned parameters in patients with heart failure.
ER  -

TOMANDL, Josef; Hana PAULOVÁ; Lenka ŠPINAROVÁ; Eva TÁBORSKÁ a Jindřich ŠPINAR. Serum matrix metalloproteinase (MMP-2) and its tissue inhibitor (TIMP-1) in relation to pro- and anti-fibrotic factors in patients with heart failure. In \textit{Proceedings from XX. Biochemický zjazd}. Bratislava: Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, 2006, s.~358. ISBN~80-969532-6-5.

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