Association of leptin and adiponectin polymorphisms with
endometrial cancer

D 2006

Association of leptin and adiponectin polymorphisms with endometrial cancer

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ, Julie BIENERTOVÁ VAŠKŮ, Anna VAŠKŮ, Atanas-Ivan BELKOV et. al.

Základní údaje

Originální název

Association of leptin and adiponectin polymorphisms with endometrial cancer

Název česky

Asociace polymorfismů v genu pro leptin a adiponektin u pacientek s endometriálním karcinomem

Autoři

CHOVANEC, Josef (203 Česká republika), Zuzana DOSTÁLOVÁ (203 Česká republika), Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, garant), Anna VAŠKŮ (203 Česká republika) a Atanas-Ivan BELKOV (203 Česká republika)

Vydání

Supp 3. London, UK, International Journal of Gynecological Cancer, od s. 780-780, 1 s. 2006

Nakladatel

Blackwell Publishing

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/06:00017550

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Endometrial cancer; obesity; leptin; adiponectin; polymorphism

Štítky

adiponectin, endometrial cancer, leptin, obesity, polymorphism

Změněno: 10. 11. 2006 14:56, prof. MUDr. Julie Dobrovolná, Ph.D.

Anotace

ORIG CZ

V originále

Adiponectin is a recently described protein secreted by adipocytes, whose circulating levels are reduced in conditions related to insulin resistance and hyperinsulinemia. Leptin is small peptide produced by adipocytes and is implicated in a great number of endocrine regulations, whose impairment might result in obesity. The aim of this study was to investigate possible associations of previously described polymorphisms within the leptin (LEP -2548 G/A) and adiponectin gene (T94G) and development of endometrial cancer. Methods: Peripherial blood samples obtained of 16 women with endometrial cancer and 14 healthy controls were evaluated for leptin -2548 G/A and adiponectin T94G polymorphisms. Results: We did not found any significant differences in genotype distributions and allelic frequencies of both examined polymorphims (LEP -2548 G/A: pg=0.13 and Adipo T94G: pg=0.75) in endometrial cancer cases and controls. The endometrial cancer cases differed significantly from the controls in baseline patients characteristics, such as weight (p= < 0.0001), height (p= < 0.0001), LDL cholesterol plasma level (p=0.02) and spontaneous abortion rate (p=0.0006). Conclusions: Our results do not clearly support the hypothesis for leptin and adiponectin polymorphisms involvement in ethiopathogenesis of endometrial cancer. However, as this was a preliminary study, the number of cases in both cohorts might not be sufficient for finding a significant association.

Česky

Naše studie nepodporuje hypotézu, že definovaná variabilita v genu pro leptin a adiponektin je faktorem velkému účinku v etiopatogenezi endometriálního karcinomu.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ, Julie BIENERTOVÁ VAŠKŮ, Anna VAŠKŮ a Atanas-Ivan BELKOV. Association of leptin and adiponectin polymorphisms with endometrial cancer. In International Journal of Gynecological Cancer. Supp 3. London, UK: Blackwell Publishing, 2006, s. 780-780.

@inproceedings{700795,
   author = {Chovanec, Josef and Dostálová, Zuzana and Bienertová Vašků, Julie and Vašků, Anna and Belkov, AtanasandIvan},
   address = {London, UK},
   booktitle = {International Journal of Gynecological Cancer},
   edition = {Supp 3},
   keywords = {Endometrial cancer; obesity; leptin; adiponectin; polymorphism},
   language = {eng},
   location = {London, UK},
   pages = {780-780},
   publisher = {Blackwell Publishing},
   title = {Association of leptin and adiponectin polymorphisms with endometrial cancer},
   year = {2006}
}

TY  - JOUR
ID  - 700795
AU  - Chovanec, Josef - Dostálová, Zuzana - Bienertová Vašků, Julie - Vašků, Anna - Belkov, Atanas-Ivan
PY  - 2006
TI  - Association of leptin and adiponectin polymorphisms with endometrial cancer
PB  - Blackwell Publishing
CY  - London, UK
KW  - Endometrial cancer
KW  - obesity
KW  - leptin
KW  - adiponectin
KW  - polymorphism
N2  - Adiponectin is a recently described protein secreted by adipocytes, whose circulating levels are reduced in conditions related to insulin resistance and hyperinsulinemia. Leptin is small peptide produced by adipocytes and is implicated in a great number of endocrine regulations, whose impairment might result in obesity. The aim of this study was to investigate possible associations of previously described polymorphisms within the leptin (LEP -2548 G/A) and adiponectin gene (T94G) and development of endometrial cancer. Methods: Peripherial blood samples obtained of 16 women with endometrial cancer and 14 healthy controls were evaluated for leptin -2548 G/A and adiponectin T94G polymorphisms. Results: We did not found any significant differences in genotype distributions and allelic frequencies of both examined polymorphims (LEP -2548 G/A: pg=0.13 and Adipo T94G: pg=0.75) in endometrial cancer cases and controls. The endometrial cancer cases differed significantly from the controls in baseline patients characteristics, such as weight (p= < 0.0001), height (p= < 0.0001), LDL cholesterol plasma level (p=0.02) and spontaneous abortion rate (p=0.0006). Conclusions: Our results do not clearly support the hypothesis for leptin and adiponectin polymorphisms involvement in ethiopathogenesis of endometrial cancer. However, as this was a preliminary study, the number of cases in both cohorts might not be sufficient for finding a significant association.
ER  -

CHOVANEC, Josef, Zuzana DOSTÁLOVÁ, Julie BIENERTOVÁ VAŠKŮ, Anna VAŠKŮ a Atanas-Ivan BELKOV. Association of leptin and adiponectin polymorphisms with endometrial cancer. In \textit{International Journal of Gynecological Cancer}. Supp 3. London, UK: Blackwell Publishing, 2006, s.~780-780.

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