Detailed Information on Publication Record
2007
Structural protein analysis of the polyvalent staphylococcal bacteriophage 812
EYER, Luděk, Roman PANTŮČEK, Zbyněk ZDRÁHAL, Hana KONEČNÁ, Petr KAŠPÁREK et. al.Basic information
Original name
Structural protein analysis of the polyvalent staphylococcal bacteriophage 812
Name in Czech
Analýza strukturních proteinů polyvalentního stafolofága 812
Authors
EYER, Luděk (203 Czech Republic, belonging to the institution), Roman PANTŮČEK (203 Czech Republic, belonging to the institution), Zbyněk ZDRÁHAL (203 Czech Republic, belonging to the institution), Hana KONEČNÁ (203 Czech Republic, belonging to the institution), Petr KAŠPÁREK (203 Czech Republic), Vladislava RŮŽIČKOVÁ (203 Czech Republic, belonging to the institution), Lenka HERNYCHOVÁ (203 Czech Republic), Jan PREISLER (203 Czech Republic, belonging to the institution) and Jiří DOŠKAŘ (203 Czech Republic, guarantor)
Edition
Proteomics, Weinheim, Wiley-VCH, 2007, 1615-9853
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
Germany
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 5.479
RIV identification code
RIV/00216224:14310/07:00020066
Organization unit
Faculty of Science
UT WoS
000243762900007
Keywords in English
staphylococcus bacteriophage; proteome; Myoviridae; Staphylococcus aureus; phage therapy
Tags
International impact, Reviewed
Změněno: 9/4/2013 14:18, prof. Mgr. Jan Preisler, Ph.D.
V originále
Phage 812 is a polyvalent phage with a very broad host range in the genus Staphylococcus, which makes it a suitable candidate for phage therapy of staphylococcal infections. This proteomic study, combining the results of both 1-DE and 2-DE followed by PMF, led to the identification of 24 virion proteins. Twenty new proteins, not yet identified by proteome analysis of closely related staphylococcal phages K and G1 were identified using this approach. Fifteen proteins were assigned unambiguously to the head-tail genome module; the remaining nine proteins are encoded by genes of the left or right arms of the phage genome. As expected, the most abundant proteins in the electrophoretic patterns are the major capsid protein, the major tail sheath protein and proteins identical to ORF 50 and ORF 95 of phage K, although their function is only putative. Identification of these 20 new proteins contributes substantially to a detailed characterization of phage virions, knowledge of which is necessary for rational phage therapy
In Czech
neuvedeno
Links
| GA203/03/0515, research and development project |
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| MSM0021622415, plan (intention) |
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