The exosome and RNA quality control in the nucleus

VAŇÁČOVÁ, Štěpánka a Richard ŠTEFL. The exosome and RNA quality control in the nucleus. EMBO REPORTS. Nature Publishing Group, London, UK: Nature Publishing Group, London, UK, roč. 8, č. 7, s. 651-657. ISSN 1469-221X. 2007.

Základní údaje

• Originální název: The exosome and RNA quality control in the nucleus
• Název česky: The exosome and RNA quality control in the nucleus
• Autoři: VAŇÁČOVÁ, Štěpánka (203 Česká republika, garant) a Richard ŠTEFL (203 Česká republika).
• Vydání: EMBO REPORTS, Nature Publishing Group, London, UK, Nature Publishing Group, London, UK, 2007, 1469-221X.

Další údaje

• Originální jazyk: angličtina
• Typ výsledku: Článek v odborném periodiku
• Obor: 10600 1.6 Biological sciences
• Stát vydavatele: Velká Británie a Severní Irsko
• Utajení: není předmětem státního či obchodního tajemství
• Impakt faktor: Impact factor: 7.450
• Kód RIV: RIV/00216224:14310/07:00022206
• Organizační jednotka: Přírodovědecká fakulta
• UT WoS: 000247651500012
• Klíčová slova anglicky: RNA decay; exoribonuclease; exosome; structure; nuclear polyadenylation; TRAMP
• Štítky: exoribonuclease, exosome, nuclear polyadenylation, RNA decay, structure, TRAMP
• Příznaky: Mezinárodní význam, Recenzováno

Anotace

To control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade not only RNA trimmings, the leftovers of RNA processing, but also incorrectly processed RNAs that contain defects. By using this mechanism, cells ensure that only high-quality RNAs are engaged in protein synthesis and other cellular processes. The exosome, a complex of several exoribonucleolytic and RNA-binding proteins, is the central 3'-end RNA degradation and processing factor in this surveillance apparatus. The exosome operates with auxiliary factors that stimulate its activity and recruit its RNA substrates in the crowded cellular environment. In this review, we discuss recent structural and functional data related to the nuclear quality-control apparatus, including the long-awaited structure of the human exosome and its activity.

Anotace česky

To control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade not only RNA trimmings, the leftovers of RNA processing, but also incorrectly processed RNAs that contain defects. By using this mechanism, cells ensure that only high-quality RNAs are engaged in protein synthesis and other cellular processes. The exosome, a complex of several exoribonucleolytic and RNA-binding proteins, is the central 3'-end RNA degradation and processing factor in this surveillance apparatus. The exosome operates with auxiliary factors that stimulate its activity and recruit its RNA substrates in the crowded cellular environment. In this review, we discuss recent structural and functional data related to the nuclear quality-control apparatus, including the long-awaited structure of the human exosome and its activity.

Návaznosti

• MSM0021622413, záměr: Název: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Proteiny v metabolismu a při interakci organismů s prostředím