PŘIKRYL, Radovan, Eva ČEŠKOVÁ, Tomáš KAŠPÁREK and Hana KUČEROVÁ. Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia. European Psychiatry. Elsevier, 2007, vol. 2007, No 22, p. 499-504, 5 pp. ISSN 0924-9338.
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Basic information
Original name Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia
Name in Czech Neurologické měkké příznaky a jejich vztah k jednoleté prognóze u první epizody schizofrenie
Authors PŘIKRYL, Radovan (203 Czech Republic, guarantor), Eva ČEŠKOVÁ (203 Czech Republic), Tomáš KAŠPÁREK (203 Czech Republic) and Hana KUČEROVÁ (203 Czech Republic).
Edition European Psychiatry, Elsevier, 2007, 0924-9338.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.875
RIV identification code RIV/00216224:14110/07:00023059
Organization unit Faculty of Medicine
UT WoS 000251119500003
Keywords in English soft signs; first episode schizophrenia; outcome
Tags first episode schizophrenia, outcome, soft signs
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Eva Češková, CSc., učo 726. Changed: 17. 6. 2009 11:06.
Objective: (a) to find a relationship between the severity of neurological soft signs at the beginning of the disease and at the one-year follow-up of schizophrenia, and (b) to investigate temporal stability of neurological soft signs within one year from the first episode schizophrenia. Methods: The trial included 92 first-episode male schizophrenic patients. Neurological soft signs were assessed on the Neurological Evaluation Scale (NES) during index hospitalization and at a one-year follow-up. The patients were divided into remitters and non-remitters according to their psychic state assessed at the one year follow-up, using the Positive and Negative Syndrome Scale (PANSS). Results: A trend of a lower score for the NES item "others" in late remitters versus non-remitters during was found during index hospitalization. At the one-year follow-up, the overall severity of the neurological soft signs was statistically significantly higher in non-remitters than in remitters. Within one year after index hospitalization, a significant reduction of neurological soft signs, with the exception of sensory integration, occurred in remitters. Within one year after index hospitalization, the non-remitters reported a significant reduction of the overall NES score. Conclusion: Our study of the population of patients with first episode schizophrenia is in accord with the findings of those existing studies which had found a connection between neurological soft signs, treatment reactivity and outcome. This association may characterize a subgroup of patients with a poor illness course and outcome. Neurological soft signs might be regarded as one of the indicators of treatment outcome in patients suffering from their first episode of schizophrenia.
Abstract (in Czech)
Neurologické měkké příznaky u pacientů s první epizodou schizofrenie souvisí s jednoletou prognózou onemocnění. Jejich vyšší intenzita koreluje s horším průběhm schizofrenie.
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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