GARAJOVA, Ingrid, Pavel FABIAN, Rudolf NENUTIL, Ilona KOCÁKOVÁ, Peter GRELL, Zina HANZELKOVÁ, Rostislav VYZULA a Marek SVOBODA. Colon carcinoma and the possible significance of T-cell population, including FOXP3-positive lymphocytes. In Proceedings of the American Association for Cancer Research. 2007. vyd. Columbia, USA: American Association for Cancer Reasearch, Inc., Philadelphia, USA, 2007. s. 133-133, 1 s. ISSN 0197-016X.
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Základní údaje
Originální název Colon carcinoma and the possible significance of T-cell population, including FOXP3-positive lymphocytes
Název česky Nádory tlustého střeva a možný význam populace T-buněk, včetně FOXP3-pozitivních lymfocytů
Autoři GARAJOVA, Ingrid, Pavel FABIAN, Rudolf NENUTIL, Ilona KOCÁKOVÁ, Peter GRELL, Zina HANZELKOVÁ, Rostislav VYZULA a Marek SVOBODA.
Vydání 2007. vyd. Columbia, USA, Proceedings of the American Association for Cancer Research, od s. 133-133, 1 s. 2007.
Nakladatel American Association for Cancer Reasearch, Inc., Philadelphia, USA
Další údaje
Originální jazyk angličtina
Typ výsledku Stať ve sborníku
Obor 30200 3.2 Clinical medicine
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Organizační jednotka Lékařská fakulta
ISSN 0197-016X
Klíčová slova anglicky colon carcinoma;T-cell lymphocytes;FOXP3
Štítky colon carcinoma, FOXP3, T-cell lymphocytes
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnil: prof. MUDr. Marek Svoboda, Ph.D., učo 19402. Změněno: 19. 12. 2007 01:16.
Anotace
Tumor-infiltrating lymphocytes (TIL) of colon carcinoma (CC) include also cytotoxic T-cells that are generally considered as prognostically favourable because of their ability to exert anti-tumor immunity. As progression of CC occurs, the question arises whether the CC microenvironment may have some suppressive capabilities. We were interested if a recently discovered subgroup of T-cells, namely regulatory T-cells (TREG, CD4+ CD25+ FOXP3+), which are able to functionally suppress immune responses and are supposed to lead to tumor progression, makes part of TIL of CC. We used immunohistochemical staining to detect lymphocytes co-expressing CD4+ and FOXP3+ in 44 cases of CC primary tumors, using formalin-fixed and paraffin-embedded sections, and commercially available monoclonal antibodies. We were first indeed to show the occurence of FOXP3+ TREG lymphocytes in CC. What we found interesting in futher studies was the localization of FOXP3+ cells. We observed them in stroma, within the epitelium, but above all they formed invasive fragment between cancer and non-cancer tissue. This localization is very suspicious to play a role in local immune system, although to explain this fact there are futher experiments undergoing in our laboratory. Investigations, in fact, are in progress on: (i) differences in TREG distribution between left/right side-localized CC, (ii) differences in TREG distribution among CC in clinical stage I-IV, (iii) TREG behaviour in cases asssociated with microsatelite instability, which is known to have more favourable clinical outcome. This project is supported by Internal Grant Agency, Ministry of Health, Czech Republic. No.: NR/9076-4.
Anotace česky
Publikace je pouze v aglickém jazyce.
Návaznosti
NR9076, projekt VaVNázev: Genomické profilování v predikci odpovědi na chemoradioterapii u pacientů s lokálně pokročilým karcinomem konečníku
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