Interleukine IL-6 gene variants and the risk of sepsis
development in children

J 2007

Interleukine IL-6 gene variants and the risk of sepsis development in children

MICHÁLEK, Jaroslav, Petra SVĚTLÍKOVÁ, Michal FEDORA, Michal KLIMOVIČ, Lucia KLAPÁČOVÁ et. al.

Základní údaje

Originální název

Interleukine IL-6 gene variants and the risk of sepsis development in children

Název česky

Genové variace IL-6 a riziko vzniku sepse u dětí

Autoři

MICHÁLEK, Jaroslav (203 Česká republika, garant, domácí), Petra SVĚTLÍKOVÁ (203 Česká republika), Michal FEDORA (203 Česká republika, domácí), Michal KLIMOVIČ (203 Česká republika), Lucia KLAPÁČOVÁ (703 Slovensko), Drahomíra BARTOŠOVÁ (203 Česká republika, domácí), Hana HRSTKOVÁ (203 Česká republika, domácí) a Jaroslav HUBÁČEK (203 Česká republika)

Vydání

Human Immunology, USA, ELSEVIER SCIENCE INC, 2007, 0198-8859

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.901

Kód RIV

RIV/00216224:14110/07:00033039

Organizační jednotka

Lékařská fakulta

UT WoS

000249751300006

Klíčová slova anglicky

interleukin; sepsis

Štítky

interleukin, sepsis

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 9. 2016 08:23, Mgr. Michal Petr

Anotace

ORIG CZ

V originále

A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care unit with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ distress syndrome (MODS) were studied together with 644 healthy controls. DNA was isolated and two IL-6 gene polymorphisms (G-174>C and G-572>C) were analyzed. The frequencies of both analyzed variants differ significantly between the group of patients and healthy controls (p = 0.02 for G-174>C and p = 0.049 for G-572>C). In addition, genetic analysis of the G-174>C IL-6 gene variant revealed significant differences between the subgroup of febrile patients and subgroup of septic shock (p = 0.0319) and between the subgroup of SIRS and septic shock (p = 0.038). In both cases the negative genotype was CC. No statistically significant differences for the IL-6 gene polymorphism G-572>C were found between the groups of patients with different diagnosis. IL-6 gene polymorphisms G-174>C and G-572>C could be the predictors of risk of development and/or the predictors of the severity of sepsis in children.

Česky

V publikaci je popisována role polymorfismu genu IL-6 u dětských pacientů a jeho vliv na rozvoj sepse.

Citovat

MICHÁLEK, Jaroslav, Petra SVĚTLÍKOVÁ, Michal FEDORA, Michal KLIMOVIČ, Lucia KLAPÁČOVÁ, Drahomíra BARTOŠOVÁ, Hana HRSTKOVÁ a Jaroslav HUBÁČEK. Interleukine IL-6 gene variants and the risk of sepsis development in children. Human Immunology. USA: ELSEVIER SCIENCE INC, 2007, roč. 68, č. 9, s. 756-60, 5 s. ISSN 0198-8859.

@article{752169,
   author = {Michálek, Jaroslav and Světlíková, Petra and Fedora, Michal and Klimovič, Michal and Klapáčová, Lucia and Bartošová, Drahomíra and Hrstková, Hana and Hubáček, Jaroslav},
   article_location = {USA},
   article_number = {9},
   keywords = {interleukin; sepsis},
   language = {eng},
   issn = {0198-8859},
   journal = {Human Immunology},
   title = {Interleukine IL-6 gene variants and the risk of sepsis development in children},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/17869650?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum},
   volume = {68},
   year = {2007}
}

TY  - JOUR
ID  - 752169
AU  - Michálek, Jaroslav - Světlíková, Petra - Fedora, Michal - Klimovič, Michal - Klapáčová, Lucia - Bartošová, Drahomíra - Hrstková, Hana - Hubáček, Jaroslav
PY  - 2007
TI  - Interleukine IL-6 gene variants and the risk of sepsis development in children
JF  - Human Immunology
VL  - 68
IS  - 9
SP  - 756-60
EP  - 756-60
PB  - ELSEVIER SCIENCE INC
SN  - 01988859
KW  - interleukin
KW  - sepsis
UR  - http://www.ncbi.nlm.nih.gov/pubmed/17869650?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
N2  - A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care unit with fever, systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, septic shock, or multiple organ distress syndrome (MODS) were studied together with 644 healthy controls. DNA was isolated and two IL-6 gene polymorphisms (G-174>C and G-572>C) were analyzed. The frequencies of both analyzed variants differ significantly between the group of patients and healthy controls (p = 0.02 for G-174>C and p = 0.049 for G-572>C). In addition, genetic analysis of the G-174>C IL-6 gene variant revealed significant differences between the subgroup of febrile patients and subgroup of septic shock (p = 0.0319) and between the subgroup of SIRS and septic shock (p = 0.038). In both cases the negative genotype was CC. No statistically significant differences for the IL-6 gene polymorphism G-572>C were found between the groups of patients with different diagnosis. IL-6 gene polymorphisms G-174>C and G-572>C could be the predictors of risk of development and/or the predictors of the severity of sepsis in children.
ER  -

MICHÁLEK, Jaroslav, Petra SVĚTLÍKOVÁ, Michal FEDORA, Michal KLIMOVIČ, Lucia KLAPÁČOVÁ, Drahomíra BARTOŠOVÁ, Hana HRSTKOVÁ a Jaroslav HUBÁČEK. Interleukine IL-6 gene variants and the risk of sepsis development in children. \textit{Human Immunology}. USA: ELSEVIER SCIENCE INC, 2007, roč.~68, č.~9, s.~756-60, 5 s. ISSN~0198-8859.

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