NAVRÁTILOVÁ, Miroslava, Jiří JARKOVSKÝ, M. HAMROVA, B. LEONARD a L. SOBOTKA. Alzheimer Disease - Malnutrition and Nutritional Support. In Clinical Nutrition, Volume 2 Supplement 2 2007, An International Journal Devoted to Clinical Nutrition and Metabolism. ISSN 1744-1161. 2007.
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Základní údaje
Originální název Alzheimer Disease - Malnutrition and Nutritional Support
Název česky Alzheimer Disease - Malnutrition and Nutritional Support
Autoři NAVRÁTILOVÁ, Miroslava, Jiří JARKOVSKÝ, M. HAMROVA, B. LEONARD a L. SOBOTKA.
Vydání Clinical Nutrition, Volume 2 Supplement 2 2007, An International Journal Devoted to Clinical Nutrition and Metabolism, 2007.
Další údaje
Originální jazyk angličtina
Typ výsledku Konferenční abstrakt
Obor 30202 Endocrinology and metabolism
Stát vydavatele Spojené státy
Utajení není předmětem státního či obchodního tajemství
Organizační jednotka Přírodovědecká fakulta
ISSN 1744-1161
Klíčová slova anglicky malnutrition; Alzheimer disease
Štítky Alzheimer disease, Malnutrition
Změnil Změnil: prof. RNDr. Luděk Bláha, Ph.D., učo 15473. Změněno: 29. 4. 2011 11:00.
Anotace
1. Alzheimer's disease (AD) is a degenerative disease of the central nervous system and its progression is often connected with a development of severe malnutrition. However, sufficient data on nutritional state and intervention regarding the progression of AD are not yet available. The aim of the present study was to assess the relationship between nutritional support and the improvement, or the maintenance, of patients' health. 2. One hundred AD patients were included in a 2 year study. Voluntary food intake was measured during the first year, following which patients were randomized into one of two groups. The study group received a 600 kcal supplement to their regular diet, whereas the control group continued on the standard diet. Nutritional parameters, voluntary food intake and mental state were monitored every 2nd month of the study period. 3. Patients with Alzheimer's dementia who died had been suffering from severe malnutrition during the last 3 months of their lives. A significant decline in mental functions was discovered in AD patients also suffering from malnutrition. Nutritional support significantly slowed the deterioration of the mental function of AD patients. 4. The present study shows that patients with AD are undernourished despite normal voluntary energy intake. Nutritional intervention significantly decreased the progression of deterioration of the mental function of AD patients, as well as other complications. It is concluded that dietary counselling and nutritional support in patients with AD are clinically important and reduce the impairment of mental function.
Anotace česky
1. Alzheimer's disease (AD) is a degenerative disease of the central nervous system and its progression is often connected with a development of severe malnutrition. However, sufficient data on nutritional state and intervention regarding the progression of AD are not yet available. The aim of the present study was to assess the relationship between nutritional support and the improvement, or the maintenance, of patients' health. 2. One hundred AD patients were included in a 2 year study. Voluntary food intake was measured during the first year, following which patients were randomized into one of two groups. The study group received a 600 kcal supplement to their regular diet, whereas the control group continued on the standard diet. Nutritional parameters, voluntary food intake and mental state were monitored every 2nd month of the study period. 3. Patients with Alzheimer's dementia who died had been suffering from severe malnutrition during the last 3 months of their lives. A significant decline in mental functions was discovered in AD patients also suffering from malnutrition. Nutritional support significantly slowed the deterioration of the mental function of AD patients. 4. The present study shows that patients with AD are undernourished despite normal voluntary energy intake. Nutritional intervention significantly decreased the progression of deterioration of the mental function of AD patients, as well as other complications. It is concluded that dietary counselling and nutritional support in patients with AD are clinically important and reduce the impairment of mental function.
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