2008
CATHEPSIN D : MANY FUNCTIONS OF ONE ASPARTIC PROTEASE
BENEŠ, Petr, Václav VĚTVIČKA a Martin FUSEKZákladní údaje
Originální název
CATHEPSIN D : MANY FUNCTIONS OF ONE ASPARTIC PROTEASE
Název česky
Katepsin D : mnoho funkcí jediné aspartátové proteázy
Autoři
BENEŠ, Petr (203 Česká republika, garant), Václav VĚTVIČKA (203 Česká republika) a Martin FUSEK (203 Česká republika)
Vydání
Critical Reviews in Oncology/Hematology, ELSEVIER, 2008, 1040-8428
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30200 3.2 Clinical medicine
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 4.589
Kód RIV
RIV/00216224:14310/08:00024162
Organizační jednotka
Přírodovědecká fakulta
UT WoS
000259895900002
Klíčová slova anglicky
Alzheimer disease; Apoptosis; Atherosclerosis; Aspartic protease; Cancer; Cathepsin D; Knock-out mice; Procathepsin D
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 25. 6. 2009 12:19, doc. Mgr. Petr Beneš, Ph.D.
V originále
For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice revealed that CD is not necessary for embryonal development, but it is indispensable for postnatal tissue homeostasis. Mutation that abolishes CD enzymatic activity causes neuronal ceroid lipofuscinosis (NCL) characterized by severe neurodegeneration, developmental regression, visual loss and epilepsy in both animals and humans. In the last decade, however, an increasing number of studies demonstrated that enzymatic function of CD is not restricted solely to acidic milieu of lysosomes with important consequences in regulation of apoptosis. In addition to CD enzymatic activity, it has been shown that apoptosis is also regulated by catalytically inactive mutants of CD which suggests that CD interacts with other important molecules and influences cell signaling. Moreover, procathepsin D (pCD), secreted from cancer cells, acts as a mitogen on both cancer and stromal cells and stimulates their pro-invasive and pro-metastatic properties. Numerous studies found that pCD/CD level represents an independent prognostic factor in a variety of cancers and is therefore considered to be a potential target of anti-cancer therapy. Studies dealing with functions of cathepsin D are complicated by the fact that there are several simultaneous forms of CD in a cell-pCD, intermediate enzymatically active CD and mature heavy and light chain CD. It became evident that these forms may differently regulate the above-mentioned processes. In this article, we review the possible functions of CD and its various forms in cells and organisms during physiological and pathological conditions.
Česky
Tento přehledný článek shrnuje nejnovější poznatky o úloze různých forem katepsinu D ve fyziologických a patofyziologických procesech na úrovni buňky i celého organismu.
Návaznosti
| IAA501630801, projekt VaV |
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| MSM0021622415, záměr |
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