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@article{770754,
author = {Vančo, J. and Marek, Jaromír and Trávníček, Z. and Račanská, E. and Muselík, J. and Švajlenová, O.},
article_location = {Amsterdam},
article_number = {4},
keywords = {copper(II); zinc(II); Schiff base; salicylaldehyde; beta-alanine; antioxidant activity; antidiabetic activity},
language = {eng},
issn = {0162-0134},
journal = {Journal of Inorganic Biochemistry},
title = {Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine},
volume = {102},
year = {2008}
}
TY - JOUR
ID - 770754
AU - Vančo, J. - Marek, Jaromír - Trávníček, Z. - Račanská, E. - Muselík, J. - Švajlenová, O.
PY - 2008
TI - Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine
JF - Journal of Inorganic Biochemistry
VL - 102
IS - 4
SP - 595-605
EP - 595-605
PB - Elsevier Science
SN - 01620134
KW - copper(II)
KW - zinc(II)
KW - Schiff base
KW - salicylaldehyde
KW - beta-alanine
KW - antioxidant activity
KW - antidiabetic activity
N2 - A series of copper(II) and zinc(II) complexes involving a tridentate 0,N,O'-donor Schiff base derived from salicylaldehyde and P-alanine I i.e. N-salicylidene-beta-alanine(2-), (L)), having the composition [Cu-2(L)(2)(H2O)].H2O (1), [Cu(L)(H2O)](n) (2), and [Zn(L)(H2O)](n) (3), have been prepared and characterized by elemental analyses, UV-visible (UV-VIS), FT-IR and ESI-MS spectra, and thermal analyses. Complexes I and 2 have been investigated by single crystal X-ray analysis and also by temperature dependent magnetic susceptibility measurements (294-80 K). All prepared complexes have been evaluated by the antiperoxynitrite activity assay and alloxan-induced diabetes model. The significant antioxidant and antidiabetic activities have been found in the case of both copper(II) complexes 1 and 2. In spite of first two complexes, the zinc(II) complex 3, as well as the potassium salt of the ligand (KHL) showed only insignificant protective effect against the tyrosine nitration in vitro.
ER -
VANČO, J., Jaromír MAREK, Z. TRÁVNÍČEK, E. RAČANSKÁ, J. MUSELÍK a O. ŠVAJLENOVÁ. Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine. \textit{Journal of Inorganic Biochemistry}. Amsterdam: Elsevier Science, 2008, roč.~102, č.~4, s.~595-605. ISSN~0162-0134.
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