VAŠKŮ, Anna, Jiří VOKURKA a Julie BIENERTOVÁ VAŠKŮ. Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results. International Journal of Colorectal Disease, Heidelberg, Německo: Springer Verlag, 2008, roč. 15/2008, xx, s. xx. ISSN 0179-1958.
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Základní údaje
Originální název Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results.
Název česky Variabilita v genech spojených s obezitou u českých pacientů se sporadickým kolorektálním karcinomem: předběžné výsledky
Autoři VAŠKŮ, Anna (203 Česká republika, garant), Jiří VOKURKA (203 Česká republika) a Julie BIENERTOVÁ VAŠKŮ (203 Česká republika).
Vydání International Journal of Colorectal Disease, Heidelberg, Německo, Springer Verlag, 2008, 0179-1958.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor Genetika a molekulární biologie
Stát vydavatele Německo
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.767
Kód RIV RIV/00216224:14110/08:00024274
Organizační jednotka Lékařská fakulta
UT WoS 000262986000006
Klíčová slova anglicky obesity-related genes; colorectal cancer; leptin; leptin receptor
Štítky Colorectal cancer, leptin, leptin receptor, obesity-related genes
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: prof. MUDr. Anna Vašků, CSc., učo 122. Změněno: 18. 6. 2009 08:12.
Anotace
BACKGROUND: Genetic variability in obesity-related genes and the resulting phenotypes are being recognized as major risk factors for colorectal cancer and/or severity of the disease. MATERIALS AND METHODS: A total of 102 patients (aged 68 +/- 10.2 years, 79 men and 23 women) and 101 age-matched (68.1 +/- 5.4 years old) individuals without colorectal cancer, 59 men and 42 women, were recruited. All the individuals were genotyped for the following subset of polymorphisms in obesity-related genes: angiotensinogen gene (M235T and -6A/G), in IL-6 gene (-174 G/C and -596 A/G), in leptin gene (-2548 A/G), and polymorphism Gln223Arg within the leptin receptor (LEPR) gene. RESULTS: A significant increase in frequency of double heterozygote genotype (MTAG) of both angiotensinogen polymorphisms in males with colorectal cancer was observed when compared to control men [odds ratio (OR) = 3.77, P (corr) = 0.001]. A marginally significant difference in genotype distribution of -174 G/C IL-6 polymorphism between the patients in stage I-II compared to patients in III-IV was found (P (g) = 0.05, P (a) = 0.173). The GG genotype of -174 G/C IL-6 polymorphism in the patients in stage III-IV carries an increased risk compared to those in stage I-II (OR = 2.83, P (corr) = 0.06). Similarly, a difference in genotype distribution of Gln223Arg in LEPR gene between the patients staged I-II compared to III-IV was observed (P (g) = 0.05). The AA genotype was shown to be risky for the patients staged III-IV (OR = 3.35, P (corr) = 0.06). CONCLUSIONS: The investigated single nucleotide polymorphisms within the genes encoding for obesity-related genes were observed to be associated both with clinical manifestation of colorectal cancer and with severity of the disease. Thus, we suggest that defined genetic variability in the genes might become DNA markers for colorectal cancer in the future.
Anotace česky
BACKGROUND: Genetic variability in obesity-related genes and the resulting phenotypes are being recognized as major risk factors for colorectal cancer and/or severity of the disease. MATERIALS AND METHODS: A total of 102 patients (aged 68 +/- 10.2 years, 79 men and 23 women) and 101 age-matched (68.1 +/- 5.4 years old) individuals without colorectal cancer, 59 men and 42 women, were recruited. All the individuals were genotyped for the following subset of polymorphisms in obesity-related genes: angiotensinogen gene (M235T and -6A/G), in IL-6 gene (-174 G/C and -596 A/G), in leptin gene (-2548 A/G), and polymorphism Gln223Arg within the leptin receptor (LEPR) gene. RESULTS: A significant increase in frequency of double heterozygote genotype (MTAG) of both angiotensinogen polymorphisms in males with colorectal cancer was observed when compared to control men [odds ratio (OR) = 3.77, P (corr) = 0.001]. A marginally significant difference in genotype distribution of -174 G/C IL-6 polymorphism between the patients in stage I-II compared to patients in III-IV was found (P (g) = 0.05, P (a) = 0.173). The GG genotype of -174 G/C IL-6 polymorphism in the patients in stage III-IV carries an increased risk compared to those in stage I-II (OR = 2.83, P (corr) = 0.06). Similarly, a difference in genotype distribution of Gln223Arg in LEPR gene between the patients staged I-II compared to III-IV was observed (P (g) = 0.05). The AA genotype was shown to be risky for the patients staged III-IV (OR = 3.35, P (corr) = 0.06). CONCLUSIONS: The investigated single nucleotide polymorphisms within the genes encoding for obesity-related genes were observed to be associated both with clinical manifestation of colorectal cancer and with severity of the disease. Thus, we suggest that defined genetic variability in the genes might become DNA markers for colorectal cancer in the future.
Návaznosti
KJB501620601, projekt VaVNázev: Funkční analýza rizikového haplotypu RAGE genu a jeho role v patogenezi hyperglykemií indukovaných změn
Investor: Akademie věd ČR, Juniorské badatelské grantové projekty
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