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@proceedings{778985,
author = {Brázda, Václav and Klusáková, Ilona and Svíženská, Ivana and Veselková, Zuzana and Jančálek, Radim and Dubový, Petr},
booktitle = {6th International Symposium on Experimental and Clinical Neurobiology},
keywords = {neuropathic pain, sciatic nerve ligature, IL-6 protein, gp130},
language = {eng},
isbn = {978-80-7399-489-1},
title = {Changes of IL-6 protein and its receptor GP130 in the rat dorsal root ganglia after spinal nerve ligature.},
year = {2008}
}
TY - CONF
ID - 778985
AU - Brázda, Václav - Klusáková, Ilona - Svíženská, Ivana - Veselková, Zuzana - Jančálek, Radim - Dubový, Petr
PY - 2008
TI - Changes of IL-6 protein and its receptor GP130 in the rat dorsal root ganglia after spinal nerve ligature.
SN - 9788073994891
KW - neuropathic pain, sciatic nerve ligature, IL-6 protein, gp130
N2 - Robust axon regeneration and neuropathic pain induction occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood. The sciatic nerve injury induces up-regulation of IL-6. We were used ligature of spinal nerves for investigation of temporal changes of IL-6 protein and its receptor gp130 in both ipsi- and contralateral lumbal (L4-L5) dorsal root ganglia. The obtained data provide evidence for changes of IL-6 protein levels not only in dorsal root ganglia's associated with damaged nerve, but also in those non-associated with nerve injury in the rat experimental neuropathic pain model.
ER -
BRÁZDA, Václav, Ilona KLUSÁKOVÁ, Ivana SVÍŽENSKÁ, Zuzana VESELKOVÁ, Radim JANČÁLEK a Petr DUBOVÝ. Changes of IL-6 protein and its receptor GP130 in the rat dorsal root ganglia after spinal nerve ligature. In \textit{6th International Symposium on Experimental and Clinical Neurobiology}. 2008. ISBN~978-80-7399-489-1.
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