2008
The effects of TGFb proteins on osteoclast differentiation
VAŇHARA, Petr, Eva LINCOVÁ, Karel SOUČEK a Jan ŠMARDAZákladní údaje
Originální název
The effects of TGFb proteins on osteoclast differentiation
Název česky
Vliv proteinů rodiny TGFb na diferenciaci osteoklastů
Autoři
VAŇHARA, Petr (203 Česká republika), Eva LINCOVÁ (203 Česká republika), Karel SOUČEK (203 Česká republika) a Jan ŠMARDA (203 Česká republika, garant)
Vydání
1. vyd. Hersonissos, Greece, Proceedings of the abstracts of the 13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine, s. 28-29, 2008
Nakladatel
International Journal of Molecular Medicine Vol. 22, supplement 1, 2008
Další údaje
Jazyk
angličtina
Typ výsledku
Stať ve sborníku
Obor
Genetika a molekulární biologie
Stát vydavatele
Řecko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.880
Kód RIV
RIV/00216224:14310/08:00024950
Organizační jednotka
Přírodovědecká fakulta
ISSN
Klíčová slova anglicky
osteoclasts; TGF beta; prostate cancer
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 9. 7. 2010 10:47, prof. RNDr. Jan Šmarda, CSc.
V originále
Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect the bone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes. In contrast, the BMP-7 and GDF-15 cytokines suppressed the RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of osteoclasts.
Česky
Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect the bone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes, such as.In contrast, the BMP-7 and GDF-15 cytokines suppressed the RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of osteoclasts.
Návaznosti
| GA301/06/0036, projekt VaV |
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| GD204/08/H054, projekt VaV |
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| MSM0021622415, záměr |
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