| KŘÍŽKOVÁ, Soňa, Ivo FABRIK, Violetta SHESTIVSKA, Tomáš ECKSCHLAGER, Jan HRABĚTA, Vojtěch ADAM, Libuše TRNKOVÁ and René KIZEK. METALLOTHIONEIN-CISPLATIN INTERACTION REVEALED BY QUARTZ CRYSTAL AND MERCURY ELECTRODE. In Electrochemistry of Nucleic Acids and Proteins. Book of Abstracts. Brno: Biofyzikální ústav AV ČR, v.v.i., 2008, p. 78-78. |
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@inproceedings{791403,
author = {Křížková, Soňa and Fabrik, Ivo and Shestivska, Violetta and Eckschlager, Tomáš and Hraběta, Jan and Adam, Vojtěch and Trnková, Libuše and Kizek, René},
address = {Brno},
booktitle = {Electrochemistry of Nucleic Acids and Proteins. Book of Abstracts},
keywords = {cisplatin; metallothionein; differential pulse voltammetry; quartz crystal},
language = {eng},
location = {Brno},
pages = {78-78},
publisher = {Biofyzikální ústav AV ČR, v.v.i.},
title = {METALLOTHIONEIN-CISPLATIN INTERACTION REVEALED BY QUARTZ CRYSTAL AND MERCURY ELECTRODE},
year = {2008}
}
TY - JOUR
ID - 791403
AU - Křížková, Soňa - Fabrik, Ivo - Shestivska, Violetta - Eckschlager, Tomáš - Hraběta, Jan - Adam, Vojtěch - Trnková, Libuše - Kizek, René
PY - 2008
TI - METALLOTHIONEIN-CISPLATIN INTERACTION REVEALED BY QUARTZ CRYSTAL AND MERCURY ELECTRODE
PB - Biofyzikální ústav AV ČR, v.v.i.
CY - Brno
KW - cisplatin
KW - metallothionein
KW - differential pulse voltammetry
KW - quartz crystal
N2 - The aim of this work was to investigate the interactions of metallothioneins with cisplatin. For this purpose we employed adsorptive transfer stripping technique with differential pulse voltammetry (mercury electrode) and gravimetric measurements (quartz crystal). Primarily we optimized experimental conditions for determination of MT using both techniques. The average concentration of the drug bound to DNA was estimated as 8.1 ng of cisplatin per 500 ng of DNA by voltammetry. Gravimetric measurements gave very similar results.
ER -
KŘÍŽKOVÁ, Soňa, Ivo FABRIK, Violetta SHESTIVSKA, Tomáš ECKSCHLAGER, Jan HRABĚTA, Vojtěch ADAM, Libuše TRNKOVÁ and René KIZEK. METALLOTHIONEIN-CISPLATIN INTERACTION REVEALED BY QUARTZ CRYSTAL AND MERCURY ELECTRODE. In \textit{Electrochemistry of Nucleic Acids and Proteins. Book of Abstracts}. Brno: Biofyzikální ústav AV ČR, v.v.i., 2008, p.~78-78.
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