Detailed Information on Publication Record
2004
DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand.
PROKOP, Radim, Jana KAŠPÁRKOVÁ, Olga NOVAKOVA, María Victoria MARINI PALOMEQUE, Ana M. PIZARRO et. al.Basic information
Original name
DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand.
Name in Czech
Interakce novych protinadorovych platinovych komplexu s DNA
Authors
PROKOP, Radim (203 Czech Republic), Jana KAŠPÁRKOVÁ (203 Czech Republic), Olga NOVAKOVA (203 Czech Republic), María Victoria MARINI PALOMEQUE (858 Uruguay), Ana M. PIZARRO (724 Spain), Carmen NAVARRO-RANNINGER (724 Spain) and Viktor BRABEC (203 Czech Republic, guarantor)
Edition
Biochemical Pharmacology, Oxford, UK, Elsevier, 2004, 0006-2952
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10610 Biophysics
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.436
RIV identification code
RIV/00216224:14310/04:00029123
Organization unit
Faculty of Science
UT WoS
000220333900012
Keywords in English
cisplatin; platinum complexes; DNA; antitumor
Tags
Tags
International impact, Reviewed
Změněno: 19/1/2009 14:32, Mgr. María Victoria Marini Palomeque, Ph.D.
V originále
The global modification of mammalian and plasmid DNAs by novel platinum compounds, trans-[PtCl(2)(NH(3))(Am)], where Am=2 -methylbutylamine or sec-butylamine was investigated in cell-free media using various biochemical and biophysical methods. These modifications were analyzed in the context of the activity of these new compounds in several tumor cell lines including those resistant to antitumor cis-diamminedichloroplatinum(II) (cisplatin). The results showed that the replacement of one amine group by 2-methylbutylamine or sec-butylamine ligand in clinically ineffective trans-diamminedichloroplatinum(II) (transplatin) resulted in a radical enhancement of its activity in tumor cell lines so that they are more cytotoxic than cisplatin and exhibited significant antitumor activity including activity in cisplatin-resistant tumor cells. Importantly, this replacement also markedly altered DNA binding mode of transplatin and reduced the efficiency of repair systems to remove the adducts of the new analogues from DNA. The results support the view that one strategy to activate trans geometry in bifunctional platinum(II) compounds including circumvention of resistance to cisplatin may consist in a chemical modification of the ineffective transplatin which results in an increased efficiency to form DNA interstrand cross-links.
In Czech
cz
Links
GA305/02/1552, research and development project |
|