2008
Depression, cortisol and somatoform dissociative symtoms
BOB, Petr; PF FREYBERGH; D. JAŠOVÁ; M. ŠUSTA; J. PAVLAT et. al.Základní údaje
Originální název
Depression, cortisol and somatoform dissociative symtoms
Název česky
Deprese, kortizol a somatoformní disociativní symptomy
Autoři
BOB, Petr (203 Česká republika, garant); PF FREYBERGH (703 Slovensko); D. JAŠOVÁ (203 Česká republika); M. ŠUSTA (203 Česká republika); J. PAVLAT (203 Česká republika); T. ZIMA (203 Česká republika); H. BENAKOVÁ (203 Česká republika); G. BIZIK (203 Česká republika); Miroslav SVĚTLÁK (203 Česká republika); J. VEVERA (203 Česká republika); J. MIKLOŠKO (203 Česká republika); K. HÁJEK (203 Česká republika) a J. RABOCH (203 Česká republika)
Vydání
NEUROENDOCRINOLOGY LETTERS, Sweden, Neuro Endocrinology Letters ISSN 0172–780X, 2008, 0172-780X
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Česká republika
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.359
Kód RIV
RIV/00216224:14110/08:00026888
Organizační jednotka
Lékařská fakulta
UT WoS
000255490000007
Klíčová slova anglicky
Depression cortisol and somatoform dissociative symtoms
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 19. 6. 2009 11:27, doc. RNDr. Petr Bob, Ph.D.
V originále
OBJECTIVE: According to recent findings neuroendocrine response related to dissociative symptoms is related to dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis but HPA axis functioning as related to dissociation is only partially understood. METHOD: With the aim to test the relationship between basal serum cortisol and dissociative symptoms measured as somatoform and psychic dissociation we performed clinical testing and biochemical analysis in 30 inpatients with diagnosis of unipolar depression (mean age 41.46, SD=13.68). RESULTS: The results show that cortisol as an index of HPA axis functioning manifests significant relationship to somatoform dissociative symptoms (r=-0.40; p=0.014). CONCLUSIONS: The result indicates relationship between HPA-axis reactivity and somatoform dissociative symptoms in unipolar depressive patients and suggests that somatoform dissociation presents a defense mechanism related to a passive coping response.
Česky
OBJECTIVE: According to recent findings neuroendocrine response related to dissociative symptoms is related to dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis but HPA axis functioning as related to dissociation is only partially understood. METHOD: With the aim to test the relationship between basal serum cortisol and dissociative symptoms measured as somatoform and psychic dissociation we performed clinical testing and biochemical analysis in 30 inpatients with diagnosis of unipolar depression (mean age 41.46, SD=13.68). RESULTS: The results show that cortisol as an index of HPA axis functioning manifests significant relationship to somatoform dissociative symptoms (r=-0.40; p=0.014). CONCLUSIONS: The result indicates relationship between HPA-axis reactivity and somatoform dissociative symptoms in unipolar depressive patients and suggests that somatoform dissociation presents a defense mechanism related to a passive coping response.
Návaznosti
| MSM0021622404, záměr |
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| 1M06039, projekt VaV |
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