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@proceedings{827482,
author = {Bittner, Michal and Hilscherová, Klára and Giesy, John P.},
booktitle = {28th International Symposium on Halogentaed Persistent Pollutants},
keywords = {humic substances; Ah receptor; dioxin; interaction; agonist},
language = {eng},
title = {IN VITRO ASSESSMENT OF INTERACTION OF HUMIC SUBSTANCES WITH 2,3,7,8-TCDD},
year = {2008}
}
TY - CONF
ID - 827482
AU - Bittner, Michal - Hilscherová, Klára - Giesy, John P.
PY - 2008
TI - IN VITRO ASSESSMENT OF INTERACTION OF HUMIC SUBSTANCES WITH 2,3,7,8-TCDD
KW - humic substances
KW - Ah receptor
KW - dioxin
KW - interaction
KW - agonist
N2 - Humic substances (HS) are ubiquitous natural products of decomposition of dead organic matter. In our previous in vitro study, we have described interaction of HS with AhR5, which has been also confirmed in vivo6. In this contribution, we summarize our new findings on interaction of both AhR-active and -inactive HS with 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD). We have observed decrease of TCDD-caused AhR-mediated effect at very high amounts of both TCDD and AhR-active HS. On the other hand, AhR-mediated effect was rather additive at lower concentrations of both TCDD and AhR-active HS. The possible mechanisms are discussed.
ER -
BITTNER, Michal, Klára HILSCHEROVÁ a John P. GIESY. IN VITRO ASSESSMENT OF INTERACTION OF HUMIC SUBSTANCES WITH 2,3,7,8-TCDD. In \textit{28th International Symposium on Halogentaed Persistent Pollutants}. 2008.
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