RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND
HEREDITY IN PSORIASIS PATIENTS

D 2009

RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS

VAŠKŮ, Vladimír, Anna VAŠKŮ, Julie BIENERTOVÁ VAŠKŮ a Veronika SLONKOVÁ

Základní údaje

Originální název

RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS

Název česky

Vztah mezi definovanymi polymorfismy v HLA-příbuzných genech a dědičností u psoriázy

Autoři

VAŠKŮ, Vladimír, Anna VAŠKŮ, Julie BIENERTOVÁ VAŠKŮ a Veronika SLONKOVÁ

Vydání

2009. vyd. Bukurešť, 6th EADV Spring Symposium on Psoriasis, od s. 310-310, 1 s. 2009

Nakladatel

EADV

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Rumunsko

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

Klíčová slova česky

HLA; psoriáza, polymorfismus; dědičnost, přidružená onemocnění

Klíčová slova anglicky

HLA; psoriasis; polymorphism; heredity; comorbidity

Štítky

comorbidity, heredity, HLA, polymorphism, psoriasis

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 6. 2009 07:51, prof. MUDr. Anna Vašků, CSc.

Anotace

ORIG CZ

V originále

The aim of the study is to associate two DNA polymorphic genotypes in HLA region (TAP1 Ile333Val, TNFa (-238 G/A) and NcoI TNFb with heredity aspects of psoriasis. A total of 209 Czech psoriatic patients, 110 men and 107 women, aged 52+-15, was enrolled in the study. Careful information about all family members affected by psoriasis was collected. The genotypes in three polymorphisms in HLA related region were detected by PCR methods with restriction analyses. We observed significantly lower occurrence of Val333 TAP-1 allele in patients with family history of psoriasis in the1st degree relatives (P=0.04), especially in parents (P=0.04). For TNFa (-238 G/A) polymorphisms, a significant decrease of the A allele was found in patients with psoriasis reported in the 2nd and the 3rd degree relatives (P=0.01). Similarly, allele B1 of NcoI TNFb polymorphism was less frequent in psoriatic patients with psoriasis documented in the 2nd and the 3rd degree relatives (P=0.008). In conclusion, the detail family history of psoriasis enables to specify more exactly existing associations among heredity aspects of psoriasis and variability in candidate genes of the disease.

Česky

Studie zkoumala vztah mezi definovanou variabilitou v HLA systému a hereditárními charakteristikami u psoriázy na souboru celkem 209 českých pacientů s psoriázou.

Návaznosti

MSM 141100002, záměr

Název: Molekulární patofyziologie multigenních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární patofyziologie multigenních chorob

Citovat

VAŠKŮ, Vladimír, Anna VAŠKŮ, Julie BIENERTOVÁ VAŠKŮ a Veronika SLONKOVÁ. RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS. In 6th EADV Spring Symposium on Psoriasis. 2009. vyd. Bukurešť: EADV, 2009, s. 310-310.

@inproceedings{830609,
   author = {Vašků, Vladimír and Vašků, Anna and Bienertová Vašků, Julie and Slonková, Veronika},
   address = {Bukurešť},
   booktitle = {6th EADV Spring Symposium on Psoriasis},
   edition = {2009},
   keywords = {HLA; psoriasis; polymorphism; heredity; comorbidity},
   language = {eng},
   location = {Bukurešť},
   pages = {310-310},
   publisher = {EADV},
   title = {RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS},
   year = {2009}
}

TY  - JOUR
ID  - 830609
AU  - Vašků, Vladimír - Vašků, Anna - Bienertová Vašků, Julie - Slonková, Veronika
PY  - 2009
TI  - RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS
PB  - EADV
CY  - Bukurešť
KW  - HLA
KW  - psoriasis
KW  - polymorphism
KW  - heredity
KW  - comorbidity
N2  - The aim of the study is to associate two DNA polymorphic genotypes in HLA region (TAP1 Ile333Val, TNFa (-238 G/A) and NcoI TNFb with heredity aspects of psoriasis. A total of 209 Czech psoriatic patients, 110 men and 107 women, aged 52+-15, was enrolled in the study. Careful information about all family members affected by psoriasis was collected. The genotypes in three polymorphisms in HLA related region were detected by PCR methods with restriction analyses. We observed significantly lower occurrence of Val333 TAP-1 allele in patients with family history of psoriasis in the1st degree relatives (P=0.04), especially in parents (P=0.04). For TNFa (-238 G/A) polymorphisms, a significant decrease of the A allele was found in patients with psoriasis reported in the 2nd and the 3rd degree relatives (P=0.01). Similarly, allele B1 of NcoI TNFb polymorphism was less frequent in psoriatic patients with psoriasis documented in the 2nd and the 3rd degree relatives (P=0.008). In conclusion, the detail family history of psoriasis enables to specify more exactly existing associations among heredity aspects of psoriasis and variability in candidate genes of the disease.
ER  -

VAŠKŮ, Vladimír, Anna VAŠKŮ, Julie BIENERTOVÁ VAŠKŮ a Veronika SLONKOVÁ. RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS. In \textit{6th EADV Spring Symposium on Psoriasis}. 2009. vyd. Bukurešť: EADV, 2009, s.~310-310.

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