2009
Rad52 sumoylation affects the efficiency of the recombination and repair
KREJČÍ, LumírZákladní údaje
Originální název
Rad52 sumoylation affects the efficiency of the recombination and repair
Název česky
SUMOylace Rad52 proteinu ovlivnuje ucinnost rekombinace a DNA opravy
Autoři
Vydání
Kréta, Řecko, 2009
Nakladatel
DNA Repair
Další údaje
Jazyk
angličtina
Typ výsledku
Audiovizuální tvorba
Obor
10600 1.6 Biological sciences
Stát vydavatele
Itálie
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Organizační jednotka
Lékařská fakulta
Klíčová slova anglicky
DNA repair; DNA damage; replication; genomic instability
Štítky
Příznaky
Mezinárodní význam
Změněno: 23. 4. 2010 15:31, doc. Mgr. Lumír Krejčí, Ph.D.
V originále
Homologous recombination (HR) plays a vital role in DNA metabolic processes including meiosis, DNA repair, DNA replication, and maintenance of rDNA homeostasis. Defects in HR can lead to pathological outcomes, including genetic diseases and cancer. Recent studies suggest that the post-translational modification by small ubiquitin-like modifier (SUMO) protein plays an important role in mitotic and meiotic recombination. We find that SUMOylation can significantly influence the biochemical properties of the modified proteins as well as their localization. The precise role of SUMOylation during recombination and DNA repair is still indistinct. Characterization of the novel effect of SUMOylation on the properties of Saccharomyces cerevisiae mediator protein Rad52 will be presented and the model for the recombination quality control discussed.
Česky
Homologous recombination (HR) plays a vital role in DNA metabolic processes including meiosis, DNA repair, DNA replication, and maintenance of rDNA homeostasis. Defects in HR can lead to pathological outcomes, including genetic diseases and cancer. Recent studies suggest that the post-translational modification by small ubiquitin-like modifier (SUMO) protein plays an important role in mitotic and meiotic recombination. We find that SUMOylation can significantly influence the biochemical properties of the modified proteins as well as their localization. The precise role of SUMOylation during recombination and DNA repair is still indistinct. Characterization of the novel effect of SUMOylation on the properties of Saccharomyces cerevisiae mediator protein Rad52 will be presented and the model for the recombination quality control discussed.
Návaznosti
| GA301/09/1917, projekt VaV |
| ||
| GD203/09/H046, projekt VaV |
| ||
| LC06030, projekt VaV |
| ||
| MSM0021622413, záměr |
|