VESELÝ, Karel, Michal JURAJDA, Rudolf NENUTIL a Marcela VESELÁ. Expression of p53, cyclin D1 and EGFR correlates with histological grade of adult soft tissue sarcomas: a study on tissue microarrays. Neoplasma. Bratislava, Slovensko: AEPress, s.r.o., 2009, roč. 56, č. 3, s. 239-244. ISSN 0028-2685.
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Základní údaje
Originální název Expression of p53, cyclin D1 and EGFR correlates with histological grade of adult soft tissue sarcomas: a study on tissue microarrays
Název česky Exprese proteinu p 53, cyklinu D1 a EGFR koreluje s histlogickým grade sarkomů u dospělých
Autoři VESELÝ, Karel, Michal JURAJDA, Rudolf NENUTIL a Marcela VESELÁ.
Vydání Neoplasma, Bratislava, Slovensko, AEPress, s.r.o. 2009, 0028-2685.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30000 3. Medical and Health Sciences
Stát vydavatele Slovensko
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 1.192
Organizační jednotka Lékařská fakulta
UT WoS 000265622200009
Klíčová slova česky Immunohistochemie; sarkom měkkých tkání; Ki-67; p53; cyklin D1; EGFR; histologický grade; tkáňové mikroereje
Klíčová slova anglicky Immunohistochemistry; soft tissue sarcoma; Ki-67; p53; cyclin D1; EGFR; histological grade; tissue microarrays
Štítky cyclin D1, EGFR, histological grade, Immunohistochemistry, Ki-67, p53, soft tissue sarcoma, tissue microarrays
Příznaky Recenzováno
Změnil Změnil: MUDr. Karel Veselý, Ph.D., učo 46531. Změněno: 6. 4. 2010 14:46.
Anotace
Soft tissue sarcomas (STSs) are rare heterogeneous tumors with variable clinical course and outcome. The management of STSs depends upon the accurate histopathological diagnosis and assessing their histological grade. Currently, core needle biopsies are becoming increasingly popular for diagnosing STSs but value of histological grading is limited from this type of specimens. To evaluate the immunohistochemical expression of p53, mdm-2, cyclin D1, p16, nm23, EGFR and Ki-67 labelling index in adult STSs patients and their association with histological grade of STSs, we analysed 101 primary untreated STSs of the limbs and trunk using the tissue microarray technique on formalin-fixed, paraffin-embedded tissue samples. The cases consisted of 15 G1, 28 G2 and 58 G2 sarcomas. Ki-67 labelling index (LI) was calculated from whole block sections for the possibility to select the most proliferative regions. The LI ranged from 1.26 to 75.5% (median 26.7%) and strongly correlated with the mitotic count (p rs for adult patients with STSs and may assist in establishment of the histological grade in STSs.
Anotace česky
Sarkomy měkkých tkání (STSs) jsou vzácnou heterogenní skupinou nádorů s variabilním klinickým průběhem. The management of STSs depends upon the accurate histopathological diagnosis and assessing their histological grade. Currently, core needle biopsies are becoming increasingly popular for diagnosing STSs but value of histological grading is limited from this type of specimens. To evaluate the immunohistochemical expression of p53, mdm-2, cyclin D1, p16, nm23, EGFR and Ki-67 labelling index in adult STSs patients and their association with histological grade of STSs, we analysed 101 primary untreated STSs of the limbs and trunk using the tissue microarray technique on formalin-fixed, paraffin-embedded tissue samples. The cases consisted of 15 G1, 28 G2 and 58 G2 sarcomas. Ki-67 labelling index (LI) was calculated from whole block sections for the possibility to select the most proliferative regions. The LI ranged from 1.26 to 75.5% (median 26.7%) and strongly correlated with the mitotic count (p rs for adult patients with STSs and may assist in establishment of the histological grade in STSs.
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