Lack of dehydroepiandrosterone in type I and II hereditary
angioedema and role of danazol in steroid hormone conversion

J 2007

Lack of dehydroepiandrosterone in type I and II hereditary angioedema and role of danazol in steroid hormone conversion

THON, Vojtěch; P. HARLE; J. SCHOLMERICH; P. KUKLINEK; Jindřich LOKAJ et. al.

Základní údaje

Originální název

Lack of dehydroepiandrosterone in type I and II hereditary angioedema and role of danazol in steroid hormone conversion

Název česky

Nedostatek dehydroepiandosteronu u pacientů s hereditárním angioedémem a úloha danazolu v konverzi steroidních hormonů

Autoři

THON, Vojtěch; P. HARLE; J. SCHOLMERICH; P. KUKLINEK; Jindřich LOKAJ a RH STRAUB

Vydání

Allergy, 2007, 0105-4538

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 5.014

Kód RIV

RIV/00216224:14110/07:00058823

Organizační jednotka

Lékařská fakulta

UT WoS

000249953300014

Klíčová slova česky

C1 inhibitor; angioedém; dehydroepiandosteron; danazol

Klíčová slova anglicky

C1 INHIBITOR; C1-INHIBITOR DEFICIENCY; MONONUCLEAR CELLS; BETA ENDORPHIN; EXPRESSION; WOMEN;

Štítky

BETA ENDORPHIN, C1 inhibitor, C1-INHIBITOR DEFICIENCY, Expression, MONONUCLEAR CELLS, women

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 4. 2013 12:30, prof. MUDr. Vojtěch Thon, Ph.D.

Anotace

ORIG CZ

V originále

Background: Hereditary angioedema (HAE) is successfully treated with danazol, a therapeutic steroid compound. To investigate hormones of the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axis in patients with HAE with and without danazol. Methods: We included 16 patients with type I HAE, nine patients with type II HAE, and 16 healthy subjects. Serum levels of adrenocorticotropic hormone (ACTH), cortisol, androstenedione, dehydroepiandrosterone (DHEA), free testosterone, and 17 beta-oestradiol were measured. Results: Serum levels of ACTH were markedly decreased in patients with type II HAE compared to the other groups (P < 0.001). Serum cortisol was similar between groups but danazol treatment decreased cortisol levels, particularly in women (P = 0.019). Serum levels of DHEA were significantly decreased in all patients with type I and II HAE compared to controls (P < 0.05), which was only partly dependent on prior danazol therapy as patients without danazol had also decreased serum levels of DHEA (P < 0.05). Furthermore, free testosterone serum levels were markedly increased in patients under danazol (P < 0.005) and the ratio of 17 beta-oestradiol/free testosterone was significantly decreased in these patients (P < 0.005). Conclusions: This study demonstrated decreased DHEA in patients with type I and II HAE independent of danazol therapy, which was particularly evident in women. It also demonstrates that danazol induced a marked up-regulation of free testosterone in relation to precursors and downstream 17 beta-oestradiol. In HAE, there seems to be a primary lack of the adrenal androgen DHEA.

Česky

Nedostatek dehydroepiandosteronu u pacientů s hereditárním angioedémem a úloha danazolu v konverzi steroidních hormonů.

Citovat

THON, Vojtěch; P. HARLE; J. SCHOLMERICH; P. KUKLINEK; Jindřich LOKAJ a RH STRAUB. Lack of dehydroepiandrosterone in type I and II hereditary angioedema and role of danazol in steroid hormone conversion. Allergy. 2007, roč. 62, č. 11, s. 1320-1325. ISSN 0105-4538.

@article{837042,
   author = {Thon, Vojtěch and Harle, P. and Scholmerich, J. and Kuklinek, P. and Lokaj, Jindřich and Straub, RH},
   article_number = {11},
   keywords = {C1 INHIBITOR; C1-INHIBITOR DEFICIENCY; MONONUCLEAR CELLS; BETA ENDORPHIN; EXPRESSION; WOMEN;},
   language = {eng},
   issn = {0105-4538},
   journal = {Allergy},
   title = {Lack of dehydroepiandrosterone in type I and II hereditary angioedema and role of danazol in steroid hormone conversion},
   volume = {62},
   year = {2007}
}

TY  - JOUR
ID  - 837042
AU  - Thon, Vojtěch - Harle, P. - Scholmerich, J. - Kuklinek, P. - Lokaj, Jindřich - Straub, RH
PY  - 2007
TI  - Lack of dehydroepiandrosterone in type I and II hereditary angioedema and role of danazol in steroid hormone conversion
JF  - Allergy
VL  - 62
IS  - 11
SP  - 1320-1325
EP  - 1320-1325
SN  - 01054538
KW  - C1 INHIBITOR
KW  - C1-INHIBITOR DEFICIENCY
KW  - MONONUCLEAR CELLS
KW  - BETA ENDORPHIN
KW  - EXPRESSION
KW  - WOMEN;
N2  - Background: Hereditary angioedema (HAE) is successfully treated with danazol, a therapeutic steroid compound. To investigate hormones of the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axis in patients with HAE with and without danazol. Methods: We included 16 patients with type I HAE, nine patients with type II HAE, and 16 healthy subjects. Serum levels of adrenocorticotropic hormone (ACTH), cortisol, androstenedione, dehydroepiandrosterone (DHEA), free testosterone, and 17 beta-oestradiol were measured. Results: Serum levels of ACTH were markedly decreased in patients with type II HAE compared to the other groups (P < 0.001). Serum cortisol was similar between groups but danazol treatment decreased cortisol levels, particularly in women (P = 0.019). Serum levels of DHEA were significantly decreased in all patients with type I and II HAE compared to controls (P < 0.05), which was only partly dependent on prior danazol therapy as patients without danazol had also decreased serum levels of DHEA (P < 0.05). Furthermore, free testosterone serum levels were markedly increased in patients under danazol (P < 0.005) and the ratio of 17 beta-oestradiol/free testosterone was significantly decreased in these patients (P < 0.005). Conclusions: This study demonstrated decreased DHEA in patients with type I and II HAE independent of danazol therapy, which was particularly evident in women. It also demonstrates that danazol induced a marked up-regulation of free testosterone in relation to precursors and downstream 17 beta-oestradiol. In HAE, there seems to be a primary lack of the adrenal androgen DHEA.
ER  -

THON, Vojtěch; P. HARLE; J. SCHOLMERICH; P. KUKLINEK; Jindřich LOKAJ a RH STRAUB. Lack of dehydroepiandrosterone in type I and II hereditary angioedema and role of danazol in steroid hormone conversion. \textit{Allergy}. 2007, roč.~62, č.~11, s.~1320-1325. ISSN~0105-4538.

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