A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL
ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

J 1994

A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

FISCHER, MB.; I. HAUBER; H. EGGENBAUER; Vojtěch THON; E. VOGEL et. al.

Základní údaje

Originální název

A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY

Název česky

Porucha časné fáze TCR zprostředkované T buněčné aktivace u pacientů s běžnou variabilní imunodeficiencí

Autoři

FISCHER, MB.; I. HAUBER; H. EGGENBAUER; Vojtěch THON; E. VOGEL; E. SCHAFFER; J. LOKAJ; J. LITZMAN; HM. WOLF a JW. MANNHALTER

Vydání

BLOOD, 1994, 0006-4971

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30102 Immunology

Stát vydavatele

Rusko

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/94:00035804

Organizační jednotka

Lékařská fakulta

UT WoS

A1994PX14600028

Klíčová slova česky

CVID; TCR; T lymfocyt

Klíčová slova anglicky

HUMAN B CELLS; PROLIFERATIVE RESPONSES; INTERFERON GAMMA; GENE EXPRESSION; INTERLEUKIN 2; HYPOGAMMAGLOBULINEMIA; IL 2; ANTIGEN; DIFFERENTIATION; ABNORMALITIES

Štítky

abnormalities, ANTIGEN, differentiation, GENE EXPRESSION, HUMAN B CELLS, hypogammaglobulinemia, IL 2, interferon gamma, interleukin 2, PROLIFERATIVE RESPONSES

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 6. 2009 00:32, prof. MUDr. Vojtěch Thon, Ph.D.

Anotace

ORIG CZ

V originále

Common variable immunodeficiency (CVID) is characterized by an impairment of specific antibody production and a decrease in all or selected Ig isotypes. Abnormalities at the level of the B cells, T cells, and antigen-presenting cells have been described. In the present study, we have focused our attention on T-cell activation in CVID. T cells from 15 of 24 patients failed to respond to recall antigens leg, tetanus toxoid, Escherichia coli), Of these 15 patients, 11 were studied in detail and showed significantly decreased T-cell proliferative responses and/or decreased interleukin-2 and interferon-gamma production on T-cell receptor-mediated stimulation with recall antigens and superantigens (staphylococcal enterotoxins [SEI); however, T-cell response to mitogens (anti-CD3 monoclonal antibody, phytohemagglutinin) was normal. The defect in interleukin-2 and interferon-gamma release on tetanus toroid stimulation could also be documented in purified CD4 T cells of the patients and was present in patients with high and normal CD8 counts alike. Furthermore, patients' T cells failed to mount a significant elevation in free intracellular calcium (Ca++ flux) in response to superantigen, whereas the response to phorbol myristate acetate and ionomycin, bypassing receptor-mediated signaling, was unimpaired. These results indicate a defect in the early phase of T-cell activation after triggering of the T-cell receptor in a significant subgroup of CVID patients.

Česky

Porucha časné fáze TCR zprostředkované T buněčné aktivace u pacientů s běžnou variabilní imunodeficiencí.

Citovat

FISCHER, MB.; I. HAUBER; H. EGGENBAUER; Vojtěch THON; E. VOGEL; E. SCHAFFER; J. LOKAJ; J. LITZMAN; HM. WOLF a JW. MANNHALTER. A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY. BLOOD. 1994, roč. 84, č. 12, s. 4234-4241, 7 s. ISSN 0006-4971.

@article{837110,
   author = {Fischer, MB. and Hauber, I. and Eggenbauer, H. and Thon, Vojtěch and Vogel, E. and Schaffer, E. and Lokaj, J. and Litzman, J. and Wolf, HM. and Mannhalter, JW.},
   article_number = {12},
   keywords = {HUMAN B CELLS; PROLIFERATIVE RESPONSES; INTERFERON GAMMA; GENE EXPRESSION; INTERLEUKIN 2; HYPOGAMMAGLOBULINEMIA; IL 2; ANTIGEN; DIFFERENTIATION; ABNORMALITIES},
   language = {eng},
   issn = {0006-4971},
   journal = {BLOOD},
   title = {A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY},
   volume = {84},
   year = {1994}
}

TY  - JOUR
ID  - 837110
AU  - Fischer, MB. - Hauber, I. - Eggenbauer, H. - Thon, Vojtěch - Vogel, E. - Schaffer, E. - Lokaj, J. - Litzman, J. - Wolf, HM. - Mannhalter, JW.
PY  - 1994
TI  - A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
JF  - BLOOD
VL  - 84
IS  - 12
SP  - 4234-4241
EP  - 4234-4241
SN  - 00064971
KW  - HUMAN B CELLS
KW  - PROLIFERATIVE RESPONSES
KW  - INTERFERON GAMMA
KW  - GENE EXPRESSION
KW  - INTERLEUKIN 2
KW  - HYPOGAMMAGLOBULINEMIA
KW  - IL 2
KW  - ANTIGEN
KW  - DIFFERENTIATION
KW  - ABNORMALITIES
N2  - Common variable immunodeficiency (CVID) is characterized by an impairment of specific antibody production and a decrease in all or selected Ig isotypes. Abnormalities at the level of the B cells, T cells, and antigen-presenting cells have been described. In the present study, we have focused our attention on T-cell activation in CVID. T cells from 15 of 24 patients failed to respond to recall antigens leg, tetanus toxoid, Escherichia coli), Of these 15 patients, 11 were studied in detail and showed significantly decreased T-cell proliferative responses and/or decreased interleukin-2 and interferon-gamma production on T-cell receptor-mediated stimulation with recall antigens and superantigens (staphylococcal enterotoxins [SEI); however, T-cell response to mitogens (anti-CD3 monoclonal antibody, phytohemagglutinin) was normal. The defect in interleukin-2 and interferon-gamma release on tetanus toroid stimulation could also be documented in purified CD4 T cells of the patients and was present in patients with high and normal CD8 counts alike. Furthermore, patients' T cells failed to mount a significant elevation in free intracellular calcium (Ca++ flux) in response to superantigen, whereas the response to phorbol myristate acetate and ionomycin, bypassing receptor-mediated signaling, was unimpaired. These results indicate a defect in the early phase of T-cell activation after triggering of the T-cell receptor in a significant subgroup of CVID patients.
ER  -

FISCHER, MB.; I. HAUBER; H. EGGENBAUER; Vojtěch THON; E. VOGEL; E. SCHAFFER; J. LOKAJ; J. LITZMAN; HM. WOLF a JW. MANNHALTER. A DEFECT IN THE EARLY PHASE OF T-CELL RECEPTOR-MEDIATED T-CELL ACTIVATION IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY. \textit{BLOOD}. 1994, roč.~84, č.~12, s.~4234-4241, 7 s. ISSN~0006-4971.

Přehled o publikaci