Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of
cyclin-dependent kinase 2

J 2007

Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2

PARUCH, Kamil, Michael DWYER, Carmen ALVAREZ, Courtney BROWN, Tin-Yau CHAN et. al.

Základní údaje

Originální název

Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2

Název česky

Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2

Autoři

PARUCH, Kamil (203 Česká republika, garant), Michael DWYER (840 Spojené státy), Carmen ALVAREZ (840 Spojené státy), Courtney BROWN (840 Spojené státy), Tin-Yau CHAN (840 Spojené státy), Ronald DOLL (840 Spojené státy), Kerry KEERTIKAR (840 Spojené státy), Chad KNUTSON (840 Spojené státy), Brian MCKITTRICK (840 Spojené státy), Jocelyn RIVERA (840 Spojené státy), Randall ROSSMAN (840 Spojené státy), Greg TUCKER (840 Spojené státy), Thierry FISCHMANN (840 Spojené státy), Alan HRUZA (840 Spojené státy), Vincent MADISON (840 Spojené státy), Amin NOMEIR (840 Spojené státy), Yaolin WANG (840 Spojené státy), Emma LEES (840 Spojené státy), David PARRY (840 Spojené státy), Nicole SGAMBELLONE (840 Spojené státy), Wolfgang SEGHEZZI (840 Spojené státy), Lesley SCHULTZ (840 Spojené státy), Fran SHANAHAN (840 Spojené státy), Derek WISWELL (840 Spojené státy), Xiaoying XU (840 Spojené státy), Quiao ZHOU (840 Spojené státy), Ray JAMES (840 Spojené státy), Vidyadhar PARADKAR (840 Spojené státy), Haengsoon PARK (840 Spojené státy), Laura ROKOSZ (840 Spojené státy), Tara STAUFFER (840 Spojené státy) a Timothy GUZI (840 Spojené státy)

Vydání

Bioorganic & Medicinal Chemistry Letters, 2007, 0960-894X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL URL URL

Impakt faktor

Impact factor: 2.604

Kód RIV

RIV/00216224:14310/07:00035878

Organizační jednotka

Přírodovědecká fakulta

UT WoS

000250906200036

Klíčová slova česky

CDK2 kináza; inhibitor; rakovina

Klíčová slova anglicky

CDK2 kinase; inibitor; cancer

Štítky

cancer, CDK2 kinase, inibitor

Příznaky

Recenzováno

Změněno: 21. 7. 2009 13:39, doc. Mgr. Kamil Paruch, Ph.D.

Anotace

ORIG CZ

V originále

Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model.

Česky

viz anotace

Citovat

PARUCH, Kamil, Michael DWYER, Carmen ALVAREZ, Courtney BROWN, Tin-Yau CHAN, Ronald DOLL, Kerry KEERTIKAR, Chad KNUTSON, Brian MCKITTRICK, Jocelyn RIVERA, Randall ROSSMAN, Greg TUCKER, Thierry FISCHMANN, Alan HRUZA, Vincent MADISON, Amin NOMEIR, Yaolin WANG, Emma LEES, David PARRY, Nicole SGAMBELLONE, Wolfgang SEGHEZZI, Lesley SCHULTZ, Fran SHANAHAN, Derek WISWELL, Xiaoying XU, Quiao ZHOU, Ray JAMES, Vidyadhar PARADKAR, Haengsoon PARK, Laura ROKOSZ, Tara STAUFFER a Timothy GUZI. Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2. Bioorganic & Medicinal Chemistry Letters. 2007, roč. 2007, č. 17, s. 6220-6223. ISSN 0960-894X.

@article{837811,
   author = {Paruch, Kamil and Dwyer, Michael and Alvarez, Carmen and Brown, Courtney and Chan, TinandYau and Doll, Ronald and Keertikar, Kerry and Knutson, Chad and McKittrick, Brian and Rivera, Jocelyn and Rossman, Randall and Tucker, Greg and Fischmann, Thierry and Hruza, Alan and Madison, Vincent and Nomeir, Amin and Wang, Yaolin and Lees, Emma and Parry, David and Sgambellone, Nicole and Seghezzi, Wolfgang and Schultz, Lesley and Shanahan, Fran and Wiswell, Derek and Xu, Xiaoying and Zhou, Quiao and James, Ray and Paradkar, Vidyadhar and Park, Haengsoon and Rokosz, Laura and Stauffer, Tara and Guzi, Timothy},
   article_number = {17},
   keywords = {CDK2 kinase; inibitor; cancer},
   language = {eng},
   issn = {0960-894X},
   journal = {Bioorganic & Medicinal Chemistry Letters},
   title = {Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2},
   url = {http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4PMJJYW-5&_user=835458&_coverDate=11%2F15%2F2007&_alid=963411855&_rdoc=2&_fmt=high&_orig=search&_cdi=5221&_sort=r&_docanchor=&view=c&_ct=2&_acct=C000045159&_version=1&_urlVersion=0&_us},
   volume = {2007},
   year = {2007}
}

TY  - JOUR
ID  - 837811
AU  - Paruch, Kamil - Dwyer, Michael - Alvarez, Carmen - Brown, Courtney - Chan, Tin-Yau - Doll, Ronald - Keertikar, Kerry - Knutson, Chad - McKittrick, Brian - Rivera, Jocelyn - Rossman, Randall - Tucker, Greg - Fischmann, Thierry - Hruza, Alan - Madison, Vincent - Nomeir, Amin - Wang, Yaolin - Lees, Emma - Parry, David - Sgambellone, Nicole - Seghezzi, Wolfgang - Schultz, Lesley - Shanahan, Fran - Wiswell, Derek - Xu, Xiaoying - Zhou, Quiao - James, Ray - Paradkar, Vidyadhar - Park, Haengsoon - Rokosz, Laura - Stauffer, Tara - Guzi, Timothy
PY  - 2007
TI  - Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2
JF  - Bioorganic & Medicinal Chemistry Letters
VL  - 2007
IS  - 17
SP  - 6220-6223
EP  - 6220-6223
SN  - 0960894X
KW  - CDK2 kinase
KW  - inibitor
KW  - cancer
UR  - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4PMJJYW-5&_user=835458&_coverDate=11%2F15%2F2007&_alid=963411855&_rdoc=2&_fmt=high&_orig=search&_cdi=5221&_sort=r&_docanchor=&view=c&_ct=2&_acct=C000045159&_version=1&_urlVersion=0&_us
N2  - Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model.
ER  -

PARUCH, Kamil, Michael DWYER, Carmen ALVAREZ, Courtney BROWN, Tin-Yau CHAN, Ronald DOLL, Kerry KEERTIKAR, Chad KNUTSON, Brian MCKITTRICK, Jocelyn RIVERA, Randall ROSSMAN, Greg TUCKER, Thierry FISCHMANN, Alan HRUZA, Vincent MADISON, Amin NOMEIR, Yaolin WANG, Emma LEES, David PARRY, Nicole SGAMBELLONE, Wolfgang SEGHEZZI, Lesley SCHULTZ, Fran SHANAHAN, Derek WISWELL, Xiaoying XU, Quiao ZHOU, Ray JAMES, Vidyadhar PARADKAR, Haengsoon PARK, Laura ROKOSZ, Tara STAUFFER a Timothy GUZI. Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2. \textit{Bioorganic \&{} Medicinal Chemistry Letters}. 2007, roč.~2007, č.~17, s.~6220-6223. ISSN~0960-894X.

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