SMOLEJ, L., C. ANDRÝS, Vladimír MAISNAR, Luděk POUR a J. MALÝ. Plasma concentrations of vascular endothelial growth factor and basic fibroblast growth factor in lymphoproliferative disorders. Acta medica (Hradec Králové). Hradec Králové, Czech Republic: Facultas Medica, Universitas Carolina, 2005, roč. 48, č. 1, s. 57-58. ISSN 1211-4286. |
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@article{838218, author = {Smolej, L. and Andrýs, C. and Maisnar, Vladimír and Pour, Luděk and Malý, J.}, article_location = {Hradec Králové, Czech Republic}, article_number = {1}, keywords = {Angiogenesis; VEGF; bFGF; Leukemia; Lymphoma; Myeloma}, language = {eng}, issn = {1211-4286}, journal = {Acta medica (Hradec Králové)}, title = {Plasma concentrations of vascular endothelial growth factor and basic fibroblast growth factor in lymphoproliferative disorders.}, volume = {48}, year = {2005} }
TY - JOUR ID - 838218 AU - Smolej, L. - Andrýs, C. - Maisnar, Vladimír - Pour, Luděk - Malý, J. PY - 2005 TI - Plasma concentrations of vascular endothelial growth factor and basic fibroblast growth factor in lymphoproliferative disorders. JF - Acta medica (Hradec Králové) VL - 48 IS - 1 SP - 57-58 EP - 57-58 PB - Facultas Medica, Universitas Carolina SN - 12114286 KW - Angiogenesis KW - VEGF KW - bFGF KW - Leukemia KW - Lymphoma KW - Myeloma N2 - Angiogenesis plays a major role in the development and progression of haematological malignancies. In our study we measured plasma concentrations of key angiogenic activators vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) using comercially available sandwich enzyme-linked immunosorbent assay (ELISA) in 37 patients with lymphoid malignancies and 20 healthy donors. We found a statistically significant increase in bFGF concentrations in patients with B-cell chronic lymphocytic leukemia (B-CLL, n=18) compared to the control group (median 118.8 vs. 9.3 pg/ml, p<0.001). However, we didn't find any significant difference in VEGF concentrations between B-CLL patients and the control group. There was also no significant increase in bFGF or VEGF in patients with multiple myeloma (n=7) and non-Hodgkin's lymphoma (n=12). Our pilot study shows that measurement of angiogenic activators in plasma is a feasible and reproducible method of angiogenesis assessment. Larger studies are needed for correlation between serum and plasma concentrations and detailed statistical evaluation including the impact on patients' survival. ER -
SMOLEJ, L., C. ANDRÝS, Vladimír MAISNAR, Luděk POUR a J. MALÝ. Plasma concentrations of vascular endothelial growth factor and basic fibroblast growth factor in lymphoproliferative disorders. \textit{Acta medica (Hradec Králové)}. Hradec Králové, Czech Republic: Facultas Medica, Universitas Carolina, 2005, roč.~48, č.~1, s.~57-58. ISSN~1211-4286.
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