Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors

P 2004

Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors

GUZI, Timothy, Kamil PARUCH, Michael DWYER, Ronald DOLL, Viyyoor GIRIJAVALLABHAN et. al.

Základní údaje

Originální název

Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors

Název česky

Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors

Autoři

GUZI, Timothy (840 Spojené státy), Kamil PARUCH (203 Česká republika, garant), Michael DWYER (840 Spojené státy), Ronald DOLL (840 Spojené státy), Viyyoor GIRIJAVALLABHAN (840 Spojené státy), Alan MALLAMS (840 Spojené státy), Carmen ALVAREZ (840 Spojené státy), Kartik KEERTIKAR (840 Spojené státy), Jocelyn RIVERA (840 Spojené státy), Tin-Yau CHAN (840 Spojené státy), Vincent MADISON (840 Spojené státy), Thierry FISCHMANN (840 Spojené státy), Lawrence DILLARD (840 Spojené státy), Vinh TRAN (840 Spojené státy), Zhen HE (840 Spojené státy), Ray JAMES (840 Spojené státy), Haengsoon PARK (840 Spojené státy), Vidyadhar PARADKAR (840 Spojené státy) a Douglas HOBBS (840 Spojené státy)

Vydání

Číslo: WO 2004/022561 A1, Vydavatel: World Intellectual Property Organization, Místo vydání: USA, Název vlastníka: Schering-Plough; Pharmacopeia, 2004

Další údaje

Jazyk

angličtina

Typ výsledku

Patent

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14310/04:00036002

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova česky

cyclin dependent kinase; inhibitor; cancer

Klíčová slova anglicky

cyclin dependent kinase; inhibitor; cancer

Štítky

cancer, Cyclin dependent kinase, inhibitor

Změněno: 25. 6. 2009 10:51, doc. Mgr. Kamil Paruch, Ph.D.

Anotace

ORIG CZ

V originále

The title pyrazolo[1,5-a]pyrimidines [I R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed.

Česky

viz Anotace

Citovat

GUZI, Timothy, Kamil PARUCH, Michael DWYER, Ronald DOLL, Viyyoor GIRIJAVALLABHAN, Alan MALLAMS, Carmen ALVAREZ, Kartik KEERTIKAR, Jocelyn RIVERA, Tin-Yau CHAN, Vincent MADISON, Thierry FISCHMANN, Lawrence DILLARD, Vinh TRAN, Zhen HE, Ray JAMES, Haengsoon PARK, Vidyadhar PARADKAR a Douglas HOBBS. Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors. 2004. Patent. Číslo: WO 2004/022561 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough; Pharmacopeia. Datum registrace: 3. 9. 2003. Datum přijetí: 18. 3. 2004.

@misc{838412,
   author = {Guzi, Timothy and Paruch, Kamil and Dwyer, Michael and Doll, Ronald and Girijavallabhan, Viyyoor and Mallams, Alan and Alvarez, Carmen and Keertikar, Kartik and Rivera, Jocelyn and Chan, TinandYau and Madison, Vincent and Fischmann, Thierry and Dillard, Lawrence and Tran, Vinh and He, Zhen and James, Ray and Park, Haengsoon and Paradkar, Vidyadhar and Hobbs, Douglas},
   keywords = {cyclin dependent kinase; inhibitor; cancer},
   language = {eng},
   title = {Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors},
   year = {2004}
}

TY  - PAT
ID  - 838412
AU  - Guzi, Timothy - Paruch, Kamil - Dwyer, Michael - Doll, Ronald - Girijavallabhan, Viyyoor - Mallams, Alan - Alvarez, Carmen - Keertikar, Kartik - Rivera, Jocelyn - Chan, Tin-Yau - Madison, Vincent - Fischmann, Thierry - Dillard, Lawrence - Tran, Vinh - He, Zhen - James, Ray - Park, Haengsoon - Paradkar, Vidyadhar - Hobbs, Douglas
PY  - 2004
TI  - Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors
KW  - cyclin dependent kinase
KW  - inhibitor
KW  - cancer
N2  - The title pyrazolo[1,5-a]pyrimidines [I R = H, alkyl, cycloalkyl, etc.; R2 = alkyl, halo, aryl, etc.; R3 = H, halo, aryl, etc.; R4 = H, halo, alkyl], useful as inhibitors of cyclin dependent kinases for treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs such as cancer, were prepd. Thus, reacting II (prepn. given) with 4-aminomethylpyridine afforded 93% III which showed IC50 of 0.020 .mu.M and 0.029 .mu.M against CDK2 kinase (cyclin A or cyclin E-dependent). The pharmaceutical compn. comprising the compd. I is claimed.
ER  -

GUZI, Timothy, Kamil PARUCH, Michael DWYER, Ronald DOLL, Viyyoor GIRIJAVALLABHAN, Alan MALLAMS, Carmen ALVAREZ, Kartik KEERTIKAR, Jocelyn RIVERA, Tin-Yau CHAN, Vincent MADISON, Thierry FISCHMANN, Lawrence DILLARD, Vinh TRAN, Zhen HE, Ray JAMES, Haengsoon PARK, Vidyadhar PARADKAR a Douglas HOBBS. \textit{Pyrazolopyrimidines as Cyclin Dependent Kinase Inhibitors}. 2004. Patent. Číslo: WO 2004/022561 A1. Vydavatel: World Intellectual Property Organization. Místo vydání: USA. Název vlastníka: Schering-Plough; Pharmacopeia. Datum registrace: 3. 9. 2003. Datum přijetí: 18. 3. 2004.

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