GIEBEL, S., B. STELLA-HOLOWIECKA, M. KRAWCZYK-KULIS, N. GÖKBUGET, D. HOELZER, Michael DOUBEK, Jiří MAYER, B. PIATKOWSKA-JAKUBAS, A.B. SKOTNICKI, H. DOMBRET, J.M. RIBERA, P.P. PICCALUGA, T. CZERW, S. KYRCZ-KRZEMIEN a J. HOLOWIECKI. Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL. Bone Marrow Transplantation. 2010, roč. 45, č. 6, s. 1095-1101. ISSN 0268-3369. Dostupné z: https://dx.doi.org/10.1038/bmt.2009.308. |
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@article{859796, author = {Giebel, S. and StellaandHolowiecka, B. and KrawczykandKulis, M. and Gökbuget, N. and Hoelzer, D. and Doubek, Michael and Mayer, Jiří and PiatkowskaandJakubas, B. and Skotnicki, A.B. and Dombret, H. and Ribera, J.M. and Piccaluga, P.P. and Czerw, T. and KyrczandKrzemien, S. and Holowiecki, J.}, article_number = {6}, doi = {http://dx.doi.org/10.1038/bmt.2009.308}, keywords = {auto transplant; ALL; minimal residual disease}, language = {eng}, issn = {0268-3369}, journal = {Bone Marrow Transplantation}, title = {Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL}, volume = {45}, year = {2010} }
TY - JOUR ID - 859796 AU - Giebel, S. - Stella-Holowiecka, B. - Krawczyk-Kulis, M. - Gökbuget, N. - Hoelzer, D. - Doubek, Michael - Mayer, Jiří - Piatkowska-Jakubas, B. - Skotnicki, A.B. - Dombret, H. - Ribera, J.M. - Piccaluga, P.P. - Czerw, T. - Kyrcz-Krzemien, S. - Holowiecki, J. PY - 2010 TI - Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL JF - Bone Marrow Transplantation VL - 45 IS - 6 SP - 1095-1101 EP - 1095-1101 SN - 02683369 KW - auto transplant KW - ALL KW - minimal residual disease N2 - The role of autologous hematopoietic SCT (autoHSCT) in the treatment of high-risk (HR) adult ALL is controversial. In this study, we retrospectively analyzed the results of autoHSCT according to the status of minimal residual disease (MRD) at transplantation, as a joint analysis of the European Study Group for Adult ALL (EWALL). Data on 123 recipients of autoHSCT, aged 31 (16–59) years, with B-lineage or T-lineage ALL were included. In a cohort of Ph-negative ALL, the probability of leukemia-free survival at 5 years was higher for patients with MRD o0.1% compared with those with MRD X0.1%. The difference was significant for T-lineage ALL, and a tendency was observed for B-lineage ALL. In a multivariate analysis, adjusted for other potential prognostic factors, high MRD level remained the only independent factor associated with increased risk of failure. We conclude that MRD determines the outcome of autoHSCT in HR adult ALL. Our results suggest the need to reevaluate the role of this treatment option in prospective trials. ER -
GIEBEL, S., B. STELLA-HOLOWIECKA, M. KRAWCZYK-KULIS, N. GÖKBUGET, D. HOELZER, Michael DOUBEK, Jiří MAYER, B. PIATKOWSKA-JAKUBAS, A.B. SKOTNICKI, H. DOMBRET, J.M. RIBERA, P.P. PICCALUGA, T. CZERW, S. KYRCZ-KRZEMIEN a J. HOLOWIECKI. Status of minimal residual disease determines outcome of autologous hematopoietic SCT in adult ALL. \textit{Bone Marrow Transplantation}. 2010, roč.~45, č.~6, s.~1095-1101. ISSN~0268-3369. Dostupné z: https://dx.doi.org/10.1038/bmt.2009.308.
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