MARINI PALOMEQUE, María Victoria a Lumír KREJČÍ. Srs2: the Odd-Job Man in DNA repair. DNA Repair, ELSEVIER, 2010, roč. 9, č. 3. ISSN 1568-7864.
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Základní údaje
Originální název Srs2: the Odd-Job Man in DNA repair
Název česky Srs2: Muž pro všechno v DNA opravě
Autoři MARINI PALOMEQUE, María Victoria (858 Uruguay, domácí) a Lumír KREJČÍ (203 Česká republika, garant, domácí).
Vydání DNA Repair, ELSEVIER, 2010, 1568-7864.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 1.6 Biological sciences
Stát vydavatele Nizozemsko
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 4.293
Kód RIV RIV/00216224:14310/10:00043104
Organizační jednotka Přírodovědecká fakulta
UT WoS 000276016800008
Klíčová slova anglicky DNA repair; DNA damage; replication; genomic instability
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnil: doc. Mgr. Lumír Krejčí, Ph.D., učo 18098. Změněno: 19. 1. 2011 05:36.
Anotace
The genome is constantly threatened by various damaging agents and maintaining its integrity is crucial in all organisms. Several repair pathways have been implicated in the removal of different types of lesions from DNA. Among them, homologous recombination (HR) plays a key role in repair of double-strand breaks (DSBs). Although HR is a highly important repair mechanism, it has to be regulated to prevent it from interfering with other DNA repair pathways, generating toxic intermediates, or blocking the progression of the replication fork. Therefore, it is not surprising that cells have evolved mechanisms that counteract untimely HR events. In the yeast Saccharomyces cerevisiae, one of the pathways responsible for regulation of HR requires the action of the SRS2 gene product. Mutations in the SRS2 gene exhibit pleiotropic recombination phenotypes ranging from anti-recombinogenic in one aspect to pro-recombinogenic in another. In addition to its role in HR, Srs2 is also involved in other DNA metabolism processes, including post-replication repair (PRR), preservation of replication fork integrity, DNA-damage checkpoint responses, DNA triplet maintenance and non-homologous end joining (NHEJ). The aim of this review is to summarize the current knowledge about Srs2 and its effect on multiple DNA metabolic processes that generally affect genome stability. It would appear that Srs2 functions as an Odd-Job Man in these processes to make sure that the jobs proceed when and where they are needed.
Anotace česky
The genome is constantly threatened by various damaging agents and maintaining its integrity is crucial in all organisms. Several repair pathways have been implicated in the removal of different types of lesions from DNA. Among them, homologous recombination (HR) plays a key role in repair of double-strand breaks (DSBs). Although HR is a highly important repair mechanism, it has to be regulated to prevent it from interfering with other DNA repair pathways, generating toxic intermediates, or blocking the progression of the replication fork. Therefore, it is not surprising that cells have evolved mechanisms that counteract untimely HR events. In the yeast Saccharomyces cerevisiae, one of the pathways responsible for regulation of HR requires the action of the SRS2 gene product. Mutations in the SRS2 gene exhibit pleiotropic recombination phenotypes ranging from anti-recombinogenic in one aspect to pro-recombinogenic in another. In addition to its role in HR, Srs2 is also involved in other DNA metabolism processes, including post-replication repair (PRR), preservation of replication fork integrity, DNA-damage checkpoint responses, DNA triplet maintenance and non-homologous end joining (NHEJ). The aim of this review is to summarize the current knowledge about Srs2 and its effect on multiple DNA metabolic processes that generally affect genome stability. It would appear that Srs2 functions as an Odd-Job Man in these processes to make sure that the jobs proceed when and where they are needed.
Návaznosti
GA301/09/1917, projekt VaVNázev: Štěpení replikačních-rekombinačních DNA meziproduktů a jejich úloha při nestabilitě genomu
Investor: Grantová agentura ČR, Standardní projekty
GD203/09/H046, projekt VaVNázev: Biochemie na rozcestí mezi in silico a in vitro
Investor: Grantová agentura ČR, Doktorské granty
LC06030, projekt VaVNázev: Biomolekulární centrum
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Centra základního výzkumu
ME10048, projekt VaVNázev: Vliv post-translačních modifikací na DNA opravu a rekombinaci.
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Program KONTAKT (ME + MEB) (jen po projekty s počátkem řešení v roce 2010), Program výzkumu a vývoje KONTAKT (ME)
MSM0021622413, záměrNázev: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumné záměry
VytisknoutZobrazeno: 24. 10. 2019 06:35