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@article{868936,
author = {Vašků, Vladimír and Bienertová Vašků, Julie and Nečas, Miroslav and Vašků, Anna},
article_location = {Milan},
article_number = {4},
keywords = {MTHFR Polymorphism Psoriasis Folate DNA methylation},
language = {eng},
issn = {1591-8890},
journal = {Clinical and Experimental Medicine},
title = {MTHFR (methylenetetrahydrofolate reductase) C677T polymorphism and psoriasis.},
url = {http://www.springerlink.com/content/w8pr742686u64541/},
volume = {9},
year = {2009}
}
TY - JOUR
ID - 868936
AU - Vašků, Vladimír - Bienertová Vašků, Julie - Nečas, Miroslav - Vašků, Anna
PY - 2009
TI - MTHFR (methylenetetrahydrofolate reductase) C677T polymorphism and psoriasis.
JF - Clinical and Experimental Medicine
VL - 9
IS - 4
SP - 327-331
EP - 327-331
PB - Springer
SN - 15918890
KW - MTHFR Polymorphism Psoriasis Folate DNA methylation
UR - http://www.springerlink.com/content/w8pr742686u64541/
N2 - The aim of the study was to evaluate possible association of MTHFR C677T gene polymorphism (NM_005957) with psoriasis. Genotypes of MTHFR C677T gene polymorphism were determined in a sample of 654 Caucasian (Czech) subjects. Case group (n = 410) included patients with psoriasis (plaque psoriasis diagnosed in 285 patients, other subtypes of psoriasis were observed in 125 patients). Control group (n = 244) consisted of healthy subjects without individual history of psoriasis, with similar age and gender characteristics. The MTHFR C677T polymorphism genotypes were determined by a polymerase chain reaction and a subsequent restriction analysis with HinfI. The genotypes of C(677)T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism were determined in a sample of 654 Caucasian (Czech) subjects. We proved a significant difference in genotype distribution (P g = 0.03) and allelic frequency (P a = 0.02) between psoriatic and control subjects. The CC (the thermostabile) genotype was significantly more frequent in psoriatic patients compared to controls. But, a significant increase of T allele in MTHFR gene was observed in patients with positive family history of diabetes (P a = 0.02) and in those with a frequent tonsillitis/tonsillectomy (P a = 0.04). No difference was observed between patients with and without positive family history of psoriasis (P a = 0.251). But, when psoriatic patients were described for FHDM, FH-Ps, and PH-T simultaneously, The highest incidence of CT and TT genotypes was calculated for psoriasis patients with positive history of psoriasis and diabetes mellitus together with personal history of repeated tonsillitis/tonsillectomy compared to patients without all these three phenotypes. In conclusion, MTHFR C677T polymorphism is marginally associated with psoriasis. The T allele (thermolabile) appears to be more frequent in psoriasis patients with positive history of psoriasis and diabetes mellitus together with personal history of repeated tonsillitis/tonsillectomy. This could reflect an inborn predisposition in complex regulation in one-carbon moieties transport in psoriatic patients and therefore, MTHFR genotype can be a part of genetic background of psoriasis.
ER -
VAŠKŮ, Vladimír, Julie BIENERTOVÁ VAŠKŮ, Miroslav NEČAS a Anna VAŠKŮ. MTHFR (methylenetetrahydrofolate reductase) C677T polymorphism and psoriasis. Online. \textit{Clinical and Experimental Medicine}. Milan: Springer, 2009, roč.~9, č.~4, s.~327-331. ISSN~1591-8890. [citováno 2024-04-24]
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