Assocition of  the ACE gene I/D polymorphism and left
myocardial systolic dysfunction in patients with acute ST
elevations myocardial infarction treated by primary PCI

a 2009

Assocition of the ACE gene I/D polymorphism and left myocardial systolic dysfunction in patients with acute ST elevations myocardial infarction treated by primary PCI

PÁVKOVÁ GOLDBERGOVÁ, Monika; Jiří PAŘENICA; Petr KALA; Martin POLOCZEK; Jan MAŇOUSEK et al.

Základní údaje

Originální název

Assocition of the ACE gene I/D polymorphism and left myocardial systolic dysfunction in patients with acute ST elevations myocardial infarction treated by primary PCI

Autoři

PÁVKOVÁ GOLDBERGOVÁ, Monika; Jiří PAŘENICA; Petr KALA; Martin POLOCZEK; Jan MAŇOUSEK; Martin TESÁK; Jindřich ŠPINAR a Anna VAŠKŮ

Vydání

Heart Failure 2009, 2009

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

Genetika a molekulární biologie

Stát vydavatele

Francie

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

Klíčová slova česky

ACE, gen, polymorfismus, infarkt myokardu

Klíčová slova anglicky

ACE, gene, polymorphism, myocardial infarction

Změněno: 1. 2. 2010 13:05, prof. RNDr. Monika Pávková Goldbergová, Ph.D.

Anotace

V originále

The ACE gene I/D polymorphism has been implicated in the development of MI, hypertension, and left ventricular hypertrophy. The goal of study was the exploration of the associations between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and post-myocardial infarction (MI) left ventricular systolic dysfunction. A total of 450 patients with acute MI with ST elevations treated by primary PCI (330 pts without heart failure - Killip I, 120 pts with acute heart failure in time of hospitalisation) and control group of 200 subjects were available for study. Echocardiography was done from 3rd day after MI during hospitalization, left ventricular systolic dysfunction was assessed according to median of ejection fraction (EF) and end-diastolic volume corrected for BSA (EDV/BSA).

Návaznosti

NR9356, projekt VaV

Název: Komplexní zhodnocení vlivu polymorfismu matrix metalloproteináz-1,2,3,9, tkáńového inhibitoru matrix metaloproteináz-1 a ACE na remodelaci levé komory a střednědobou prognózu po akutním infarktu mykardu s ST elevacemi léčeném primární PCI

Investor: Ministerstvo zdravotnictví ČR, Komplexní zhodnocení vlivu polymorfismu matrix metalloproteináz-1,2,3,9, tkáńového inhibitoru matrix metaloproteináz-1 a ACE na remodelaci levé komory a střednědobou prognózu po akutním infarktu mykardu s ST elevacemi léčeném primární PCI

Citovat

PÁVKOVÁ GOLDBERGOVÁ, Monika; Jiří PAŘENICA; Petr KALA; Martin POLOCZEK; Jan MAŇOUSEK; Martin TESÁK; Jindřich ŠPINAR a Anna VAŠKŮ. Assocition of the ACE gene I/D polymorphism and left myocardial systolic dysfunction in patients with acute ST elevations myocardial infarction treated by primary PCI. In Heart Failure 2009. 2009.

@proceedings{869974,
   author = {Pávková Goldbergová, Monika and Pařenica, Jiří and Kala, Petr and Poloczek, Martin and Maňousek, Jan and Tesák, Martin and Špinar, Jindřich and Vašků, Anna},
   booktitle = {Heart Failure 2009},
   keywords = {ACE, gene, polymorphism, myocardial infarction},
   language = {eng},
   title = {Assocition of the ACE gene I/D polymorphism and left myocardial systolic dysfunction in patients with acute ST elevations myocardial infarction treated by primary PCI},
   year = {2009}
}

TY  - CONF
ID  - 869974
AU  - Pávková Goldbergová, Monika - Pařenica, Jiří - Kala, Petr - Poloczek, Martin - Maňousek, Jan - Tesák, Martin - Špinar, Jindřich - Vašků, Anna
PY  - 2009
TI  - Assocition of the ACE gene I/D polymorphism and left myocardial systolic dysfunction in patients with acute ST elevations myocardial infarction treated by primary PCI
KW  - ACE, gene, polymorphism, myocardial infarction
N2  - The ACE gene I/D polymorphism has been implicated in the development of MI, hypertension, and left ventricular hypertrophy. The goal of study was the exploration of the associations between the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and post-myocardial infarction (MI) left ventricular systolic dysfunction. A total of 450 patients with acute MI with ST elevations treated by primary PCI (330 pts without heart failure - Killip I, 120 pts with acute heart failure in time of hospitalisation) and control group of 200 subjects were available for study. Echocardiography was done from 3rd day after MI during hospitalization, left ventricular systolic dysfunction was assessed according to median of ejection fraction (EF) and end-diastolic volume corrected for BSA (EDV/BSA).
ER  -

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