| KŘEN, Leoš, Katarína MÚČKOVÁ, Eva LŽIČAŘOVÁ, Marek SOVA, Václav VYBÍHAL, Tomáš SVOBODA, Pavel FADRUS, Martin SMRČKA, Ondřej SLABÝ, Radek LAKOMÝ, Petr VAŇHARA, Zdenka KŘENOVÁ a Jaroslav MICHÁLEK. Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity? Journal of Neuroimmunology. Netherlands: Elsevier/North-Holland, 2010, roč. 220, 1-2, s. 131-135. ISSN 0165-5728. Dostupné z: https://dx.doi.org/10.1016/j.jneuroim.2010.01.014. |
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@article{883791,
author = {Křen, Leoš and Múčková, Katarína and Lžičařová, Eva and Sova, Marek and Vybíhal, Václav and Svoboda, Tomáš and Fadrus, Pavel and Smrčka, Martin and Slabý, Ondřej and Lakomý, Radek and Vaňhara, Petr and Křenová, Zdenka and Michálek, Jaroslav},
article_location = {Netherlands},
article_number = {1-2},
doi = {http://dx.doi.org/10.1016/j.jneuroim.2010.01.014},
keywords = {HLA-E; HLA-G; Microglia; Glioblastoma},
language = {eng},
issn = {0165-5728},
journal = {Journal of Neuroimmunology},
title = {Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity?},
volume = {220},
year = {2010}
}
TY - JOUR
ID - 883791
AU - Křen, Leoš - Múčková, Katarína - Lžičařová, Eva - Sova, Marek - Vybíhal, Václav - Svoboda, Tomáš - Fadrus, Pavel - Smrčka, Martin - Slabý, Ondřej - Lakomý, Radek - Vaňhara, Petr - Křenová, Zdenka - Michálek, Jaroslav
PY - 2010
TI - Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity?
JF - Journal of Neuroimmunology
VL - 220
IS - 1-2
SP - 131-135
EP - 131-135
PB - Elsevier/North-Holland
SN - 01655728
KW - HLA-E
KW - HLA-G
KW - Microglia
KW - Glioblastoma
N2 - The possible role of immune-modulatory nonclassical molecules HLA-G and HLA-E in an anti-tumoral response and development of glioblastoma is not well characterized. In this study, we evaluated an expression of HLA-G and HLA-E by activated tumor infiltrating microglia/macrophages. We found production of FILA-G and HLA-E by tumor infiltrating activated microglia/macrophages in a majority of glioblastomas. We speculate that the expression of these molecules by activated microglia/CNS macrophages plays a role in the anti-tumoral immunity in the development of glioblastoma. Mechanisms of microglia-glioblastoma cell interactions with respect to the expression of these molecules deserves further study.
ER -
KŘEN, Leoš, Katarína MÚČKOVÁ, Eva LŽIČAŘOVÁ, Marek SOVA, Václav VYBÍHAL, Tomáš SVOBODA, Pavel FADRUS, Martin SMRČKA, Ondřej SLABÝ, Radek LAKOMÝ, Petr VAŇHARA, Zdenka KŘENOVÁ a Jaroslav MICHÁLEK. Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity? \textit{Journal of Neuroimmunology}. Netherlands: Elsevier/North-Holland, 2010, roč.~220, 1-2, s.~131-135. ISSN~0165-5728. Dostupné z: https://dx.doi.org/10.1016/j.jneuroim.2010.01.014.
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