| KNOPFOVÁ, Lucia, Filip TRČKA, Petr BENEŠ a Jan ŠMARDA. c-Myb promotes invasivity of breast cancer cells. In 21st Meeting of the European Association for Cancer Research Europe, Oslo, Norway, Eur J Cancer. 2010. ISSN 1359-6349. |
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@proceedings{890755,
author = {Knopfová, Lucia and Trčka, Filip and Beneš, Petr and Šmarda, Jan},
booktitle = {21st Meeting of the European Association for Cancer Research Europe, Oslo, Norway, Eur J Cancer},
keywords = {c-Myb; invasivity; breast cancer},
language = {eng},
title = {c-Myb promotes invasivity of breast cancer cells},
year = {2010}
}
TY - CONF
ID - 890755
AU - Knopfová, Lucia - Trčka, Filip - Beneš, Petr - Šmarda, Jan
PY - 2010
TI - c-Myb promotes invasivity of breast cancer cells
KW - c-Myb
KW - invasivity
KW - breast cancer
N2 - The aim of this study was to assess the role of the c-Myb protein in control of invasivity of breast cancer cells. MDA-MB-231 breast cancer cells were transfected with the c-Myb coding cDNA to prepare MDA-MB-231MYBup derivatives. MDA-MB-231MYBup cells were significantly more active in both motility and invasion than controls as determined by Cultrex cell invasion assay. This was clearly confirmed by real-time analysis of cell migration/invasion. To address the mechanism of c-Myb-enhanced breast cancer cell invasion, we examined the role of c-Myb in control of expression and activity of some of the proteases involved in degradation of extracellular matrix. We found that c-Myb enhanced production of cathepsin D and matrix metaloproteinases in MDA-MB-231MYBup cells. These results suggest a novel role of c-Myb protein in control of tumor invasion and metastatic progression.
ER -
KNOPFOVÁ, Lucia, Filip TRČKA, Petr BENEŠ a Jan ŠMARDA. c-Myb promotes invasivity of breast cancer cells. In \textit{21st Meeting of the European Association for Cancer Research Europe, Oslo, Norway, Eur J Cancer}. 2010. ISSN~1359-6349.
|
