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@article{891840, author = {Salzman, Richard and Pácal, Lukáš and Kaňková, Kateřina and Tomandl, Josef and Horáková, Zuzana and Tothova, Eva and Kostřica, Rom}, article_number = {6}, keywords = {Glutathione peroxidase; Head and neck cancer; Malondialdehyde; oxidative stress; prognostic marker}, language = {eng}, issn = {1341-9625}, journal = {International Journal of Clinical Oncology}, title = {High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma}, url = {http://www.springerlink.com/content/3826221v40j17251/fulltext.pdf}, volume = {15}, year = {2010} }
TY - JOUR ID - 891840 AU - Salzman, Richard - Pácal, Lukáš - Kaňková, Kateřina - Tomandl, Josef - Horáková, Zuzana - Tothova, Eva - Kostřica, Rom PY - 2010 TI - High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma JF - International Journal of Clinical Oncology VL - 15 IS - 6 SP - 565-570 EP - 565-570 SN - 13419625 KW - Glutathione peroxidase KW - Head and neck cancer KW - Malondialdehyde KW - oxidative stress KW - prognostic marker UR - http://www.springerlink.com/content/3826221v40j17251/fulltext.pdf N2 - BACKGROUND: The aim of the study was to investigate the relationships among (a) glutathione peroxidase (GPx) and malondialdehyde (MDA); (b) oncological characteristics (i.e., TNM classification, tumor grade), and; (c) prognosis of head and neck squamous cell carcinoma. METHODS: In a prospective cohort study, we followed 88 patients for 67.4 months (median 40.3) after surgery for head and neck squamous cell carcinoma. Activity of GPx was determined by ELISA and plasma MDA concentration by liquid chromatography. RESULTS: Lower GPx activity was observed in the T3/4 patients than in the T1/2 group. Tumor grade was significantly correlated with both GPx (P = 0.001) and MDA (P = 0.05, both Spearman). The perioperative level of MDA was higher in patients who later recurred during the follow-up period (n = 15) than in the complete remission group (P = 0.01, Mann-Whitney). Median disease-free interval and overall survival in the group with MDA > median were 29.5 and 32.0 months, respectively, and 38.4 and 40.3 months in the patient group with MDA ER -
SALZMAN, Richard, Lukáš PÁCAL, Kateřina KAŇKOVÁ, Josef TOMANDL, Zuzana HORÁKOVÁ, Eva TOTHOVA a Rom KOSTŘICA. High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma. \textit{International Journal of Clinical Oncology}. 2010, roč.~15, č.~6, s.~565-570. ISSN~1341-9625.
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