LITZMAN, Jiří, Dagmar ŠTIKAROVSKÁ, Zdenka PIKULOVÁ, Tomáš PAVLÍK, Sáva PEŠÁK, Vojtěch THON, Pavel KUKLÍNEK a Jindřich LOKAJ. Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2010, roč. 153, č. 1, s. 95-101. ISSN 1018-2438. doi:10.1159/000301584.
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Základní údaje
Originální název Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre
Autoři LITZMAN, Jiří (203 Česká republika, garant, domácí), Dagmar ŠTIKAROVSKÁ (203 Česká republika), Zdenka PIKULOVÁ (203 Česká republika), Tomáš PAVLÍK (203 Česká republika, domácí), Sáva PEŠÁK (203 Česká republika, domácí), Vojtěch THON (203 Česká republika, domácí), Pavel KUKLÍNEK (203 Česká republika, domácí) a Jindřich LOKAJ (203 Česká republika, domácí).
Vydání INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2010, 1018-2438.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30102 Immunology
Stát vydavatele Švýcarsko
Utajení není předmětem státního či obchodního tajemství
Impakt faktor Impact factor: 2.235
Kód RIV RIV/00216224:14110/10:00051417
Organizační jednotka Lékařská fakulta
Doi http://dx.doi.org/10.1159/000301584
UT WoS 000279595800012
Klíčová slova anglicky Common variable immunodeficiency; X-linked agammaglobulinaemia; Immunoglobulins
Příznaky Mezinárodní význam
Změnil Změnil: Mgr. Michal Petr, učo 65024. Změněno: 20. 4. 2012 11:15.
Anotace
Background: The classical clinical manifestation of untreated immunoglobulin deficiency comprises predominantly recurrent and complicated respiratory tract infections. Before the 1980s, little was known about the clinical manifestation of immunodeficiency in the general medical population, and also the availability of serum immunoglobulin laboratory determination was not sufficient, leading to a significant diagnostic delay. Methods: We have analysed the diagnostic delay and referral diagnoses in patients in whom any form of primary hypogammaglobulinaemia had been diagnosed at our department, which was established in 1981. Results: Comparing the diagnostic delay in the 1980s (19 patients, median 5.5 years), the 1990s (37 patients, median 3.5 years) and the years 2001-2008 (33 patients, median 1 year), a significant decrease was observed (Spearmans correlation coefficient). Also, the median number of pneumonia episodes during the diagnostic delay decreased from 5 in the 1980s, to 1 in the 1990s and to 0 in the period of 2001-2008 (Spearmans correlation coefficient). While in the 1980s 17 of the 19 patients had pneumonia in their past history, in the period of 2001-2008 only 13 of the 33 patients were concerned. Conclusions: Our observation documents improved awareness of immunodeficiencies among physicians. It is supposed that earlier diagnosis will prevent complications, improve the quality of life and even survival of hypogammaglobulinaemic patients.
VytisknoutZobrazeno: 26. 10. 2020 12:17