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@article{893189,
author = {McGregor, Tracey and Balcarová, Zdeňka and Qu, Yun and Tran, MyandChau and Žaludová, Renata and Brabec, Viktor and Farrell, Nicholas},
article_number = {1-2},
keywords = {DNA; polynuclear platinum complexes},
language = {eng},
issn = {0162-0134},
journal = {JOURNAL OF INORGANIC BIOCHEMISTRY},
title = {Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes},
volume = {77},
year = {1999}
}
TY - JOUR
ID - 893189
AU - McGregor, Tracey - Balcarová, Zdeňka - Qu, Yun - Tran, My-Chau - Žaludová, Renata - Brabec, Viktor - Farrell, Nicholas
PY - 1999
TI - Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes
JF - JOURNAL OF INORGANIC BIOCHEMISTRY
VL - 77
IS - 1-2
SN - 01620134
KW - DNA
KW - polynuclear platinum complexes
N2 - In this work, the B to Z transition of poly(dGdC).poly(dGdC) and the B to A transition of poly(dG).poly(dC) and of calf thymus (CT) DNA fragments modified by antitumor bifunctional polynuclear platinum complexes were investigated by circular dichroism (CD). The transition from the B to Z form of DNA was inducible with all three compounds studied, as indicated by an inversion of the B form spectra. The B to A transition in poly(dG) poly(dC) was induced easily by platinum complex binding alone, while the B to A transition in CT DNA was induced by ethanol but inhibited by coordination of all polynuclear platinum compounds used here. It was shown that the compound [(cisPtCl(NH3)(2))(2) mu(H2N(CH2)(6)NH2)] (NO3)(2) (1,1/c,c) was most effective at inhibiting the B to A transition in CT DNA, and [(transPtCl(NH3)(2))(,2 mu)(trans- Pt(NH3)(2)(H2N(CH2)(6)NH2)(2))](NO3)(4) (1,0,1/t,t,t) was least effective, while the effectiveness of [(transPtCl(NH3)(2))(,2) mu(H,2N(CH2)(6)NH2)] (NO3)(2) (1,1/t,t) fell between.
ER -
MCGREGOR, Tracey, Zdeňka BALCAROVÁ, Yun QU, My-Chau TRAN, Renata ŽALUDOVÁ, Viktor BRABEC a Nicholas FARRELL. Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes. \textit{JOURNAL OF INORGANIC BIOCHEMISTRY}. 1999, roč.~77, 1-2, 4 s. ISSN~0162-0134.
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