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@article{893190,
author = {Žákovská, Alena and Nováková, Olga and Balcarová, Zdeňka and Bierbach, Uli and Farrell, Nicholas and Brabec, Viktor},
article_number = {3},
keywords = {DNA; platinum drug; quinoline; antitumor activity; conformation},
language = {eng},
issn = {0014-2956},
journal = {EUROPEAN JOURNAL OF BIOCHEMISTRY},
title = {DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]},
volume = {254},
year = {1998}
}
TY - JOUR
ID - 893190
AU - Žákovská, Alena - Nováková, Olga - Balcarová, Zdeňka - Bierbach, Uli - Farrell, Nicholas - Brabec, Viktor
PY - 1998
TI - DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]
JF - EUROPEAN JOURNAL OF BIOCHEMISTRY
VL - 254
IS - 3
SN - 00142956
KW - DNA
KW - platinum drug
KW - quinoline
KW - antitumor activity
KW - conformation
N2 - Recent observations that several trans platinum complexes exhibit antitumor activity including activity in cisplatin-resistant tumor cells, violates the classical structure/activity relationships of platinum(II) complexes. According to these relationships, only bifunctional platinum(II) complexes with cis oriented leaving ligands should be therapeutically active. In order to contribute to the understanding of mechanisms underlying the antitumor activity of these new trans platinum analogs, various biochemical and biophysical methods as well as molecular modeling techniques were employed to study the modifications of DNA by antitumor trans[PtCl2(NH3)(quinoline)]. The results indicated that trans[PtCl2(NH3)(quinoline)] coordinated monofunctionally to DNA with a similar rate as transplatin. The overall rate of the rearrange ment to bifunctional adducts was also similar to that observed in the case of DNA modification by transplatin, i.e, it was relatively slow.
ER -
ŽÁKOVSKÁ, Alena, Olga NOVÁKOVÁ, Zdeňka BALCAROVÁ, Uli BIERBACH, Nicholas FARRELL a Viktor BRABEC. DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]. \textit{EUROPEAN JOURNAL OF BIOCHEMISTRY}. 1998, roč.~254, č.~3, 11 s. ISSN~0014-2956.
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