DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]

J 1998

DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]

ŽÁKOVSKÁ, Alena; Olga NOVÁKOVÁ; Zdeňka BALCAROVÁ; Uli BIERBACH; Nicholas FARRELL et al.

Základní údaje

Originální název

DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]

Autoři

ŽÁKOVSKÁ, Alena; Olga NOVÁKOVÁ; Zdeňka BALCAROVÁ; Uli BIERBACH; Nicholas FARRELL a Viktor BRABEC

Vydání

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 0014-2956

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Ukrajina

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.249

Označené pro přenos do RIV

Ano

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

DNA; platinum drug; quinoline; antitumor activity; conformation

Změněno: 5. 8. 2010 13:47, RNDr. Kamila Neplechová, Ph.D.

Anotace

V originále

Recent observations that several trans platinum complexes exhibit antitumor activity including activity in cisplatin-resistant tumor cells, violates the classical structure/activity relationships of platinum(II) complexes. According to these relationships, only bifunctional platinum(II) complexes with cis oriented leaving ligands should be therapeutically active. In order to contribute to the understanding of mechanisms underlying the antitumor activity of these new trans platinum analogs, various biochemical and biophysical methods as well as molecular modeling techniques were employed to study the modifications of DNA by antitumor trans[PtCl2(NH3)(quinoline)]. The results indicated that trans[PtCl2(NH3)(quinoline)] coordinated monofunctionally to DNA with a similar rate as transplatin. The overall rate of the rearrange ment to bifunctional adducts was also similar to that observed in the case of DNA modification by transplatin, i.e, it was relatively slow.

Návaznosti

GA204/97/P028, projekt VaV

Název: Biofyzikální analýza vlivu protinádorově účinných komplexů ruthenia na DNA

Citovat

ŽÁKOVSKÁ, Alena; Olga NOVÁKOVÁ; Zdeňka BALCAROVÁ; Uli BIERBACH; Nicholas FARRELL a Viktor BRABEC. DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1998, roč. 254, č. 3, 11 s. ISSN 0014-2956.

@article{893190,
   author = {Žákovská, Alena and Nováková, Olga and Balcarová, Zdeňka and Bierbach, Uli and Farrell, Nicholas and Brabec, Viktor},
   article_number = {3},
   keywords = {DNA; platinum drug; quinoline; antitumor activity; conformation},
   language = {eng},
   issn = {0014-2956},
   journal = {EUROPEAN JOURNAL OF BIOCHEMISTRY},
   title = {DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]},
   volume = {254},
   year = {1998}
}

TY  - JOUR
ID  - 893190
AU  - Žákovská, Alena - Nováková, Olga - Balcarová, Zdeňka - Bierbach, Uli - Farrell, Nicholas - Brabec, Viktor
PY  - 1998
TI  - DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]
JF  - EUROPEAN JOURNAL OF BIOCHEMISTRY
VL  - 254
IS  - 3
SN  - 00142956
KW  - DNA
KW  - platinum drug
KW  - quinoline
KW  - antitumor activity
KW  - conformation
N2  - Recent observations that several trans platinum complexes exhibit antitumor activity including activity in cisplatin-resistant tumor cells, violates the classical structure/activity relationships of platinum(II) complexes. According to these relationships, only bifunctional platinum(II) complexes with cis oriented leaving ligands should be therapeutically active. In order to contribute to the understanding of mechanisms underlying the antitumor activity of these new trans platinum analogs, various biochemical and biophysical methods as well as molecular modeling techniques were employed to study the modifications of DNA by antitumor trans[PtCl2(NH3)(quinoline)]. The results indicated that trans[PtCl2(NH3)(quinoline)] coordinated monofunctionally to DNA with a similar rate as transplatin. The overall rate of the rearrange ment to bifunctional adducts was also similar to that observed in the case of DNA modification by transplatin, i.e, it was relatively slow.
ER  -

ŽÁKOVSKÁ, Alena; Olga NOVÁKOVÁ; Zdeňka BALCAROVÁ; Uli BIERBACH; Nicholas FARRELL a Viktor BRABEC. DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)]. \textit{EUROPEAN JOURNAL OF BIOCHEMISTRY}. 1998, roč.~254, č.~3, 11 s. ISSN~0014-2956.

Přehled o publikaci