KNOPFOVÁ, Lucia, Lucie PEKARČÍKOVÁ, Filip TRČKA, Petr BENEŠ a Jan ŠMARDA. The c-Myb protein promotes motility and invasion of breast cancer cells. In The EMBO meeting 2010, Barcelona,Spain,. 2010. |
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@proceedings{897033, author = {Knopfová, Lucia and Pekarčíková, Lucie and Trčka, Filip and Beneš, Petr and Šmarda, Jan}, booktitle = {The EMBO meeting 2010, Barcelona,Spain,}, keywords = {c-Myb; invasion; migration; breast carcinoma}, language = {eng}, title = {The c-Myb protein promotes motility and invasion of breast cancer cells}, year = {2010} }
TY - CONF ID - 897033 AU - Knopfová, Lucia - Pekarčíková, Lucie - Trčka, Filip - Beneš, Petr - Šmarda, Jan PY - 2010 TI - The c-Myb protein promotes motility and invasion of breast cancer cells KW - c-Myb KW - invasion KW - migration KW - breast carcinoma N2 - c-Myb is a key regulator of progenitor cells in bone marrow, colonic crypts and adult brain. Activation of c-myb is associated with leukemias and solid tumors. The aim of this study was to assess the role of the c-Myb protein in control of invasion of breast cancer cells. c-Myb overexpression enhanced migration and invasiveness of MDA-MB-231 cells as determined by transwell cell invasion assay and real-time analysis of cell migration and invasion using the xCELLigence RTCA system. qRT-PCR analysis revealed c-Myb-dependent upregulation of the genes coding for proteases that are involved in invasive behavior of MDA-MB-231 cells: increased production of cathepsin D and matrix metalloproteinase 9 (MMP9) in MDA-MB-231MYBup cells were further confirmed by western blotting. Transactivation assay revealed that c-Myb can activate transcription from the cathepsin D promoter. This denotes cathepsin D as a novel Myb-target gene. c-Myb promotes motility and invasivity of breast cancer MDA-MB-231 cells. ER -
KNOPFOVÁ, Lucia, Lucie PEKARČÍKOVÁ, Filip TRČKA, Petr BENEŠ a Jan ŠMARDA. The c-Myb protein promotes motility and invasion of breast cancer cells. In \textit{The EMBO meeting 2010, Barcelona,Spain,}. 2010.
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